Book Detail:
Author: R.D. Goldman
Publisher: Springer Science & Business Media
ISBN: 1475796048
Size: 66.25 MB
Format: PDF, ePub
Release Date: 2013-06-29
Category: Science
Language: en
View: 302
Status: Available

Get Book
Book Description
Download PDF Cellular And Molecular Biology Of Intermediate Filaments eBook. You can read online on your kindle, Android, iPhone, iPad. Research activity on intermediate filaments (IF) has increased dramatically over the past decade. For the most part, this surge of interest is due to their identification as ubiquitous constituents of the cytoskeleton and karyoskeleton (nuclear matrix) of eukaryotic cells and the fact that we know very little regarding their functions. In sharp contrast to the other major cytoskeletal systems, microfilaments and microtubules, IF exhibit a high degree of heterogeneity with regard to their protein subunit composition. Indeed, one can only marvel at the number of different IF polypeptides, their associated proteins (IFAP) and, consequently, the number of genes involved in encoding the multiple constituents of the various IF networks found in different cell types. The chapters in this book demonstrate how various experimental approaches involv ing cellular, molecular, biochemical, and immunological methods have been utilized to generate information regarding the structure and function of IF. To this end, we have gathered together chapters from experts in the major fields of IF research. In each chapter, the authors have combined reviews of the available scientific literature with their own ideas on current and future directions for IF research. The chapters have been divided into five major sections which are concerned with the subcellular organization of IF, the molecular structure of IF, the differential expression of IF genes, descriptions of associ ated proteins involved in the intracellular organization of IF, and finally an analysis of the changes seen in IF in pathological conditions.

---

Book Detail:
Author: J.W. Shay
Publisher: Springer Science & Business Media
ISBN: 1461321514
Size: 43.47 MB
Format: PDF, Mobi
Release Date: 2013-11-11
Category: Science
Language: en
View: 3079
Status: Available

Get Book
Book Description
Download PDF Cell And Molecular Biology Of The Cytoskeleton eBook. You can read online on your kindle, Android, iPhone, iPad.

---

Book Detail:
Author:
Publisher: Academic Press
ISBN: 0128034912
Size: 50.93 MB
Format: PDF, Mobi
Release Date: 2016-01-18
Category: Medical
Language: en
View: 1249
Status: Available

Get Book
Book Description
Download PDF Intermediate Filament Proteins eBook. You can read online on your kindle, Android, iPhone, iPad. Intermediate Filament Proteins, the latest volume in the Methods in Enzymology series covers all the intermediate filaments in vertebrates and invertebrates, providing a unique understanding of the multiple different tissue-specific intermediate filaments. This volume also covers the latest methods that are currently being used to study intermediate filament protein function and dynamics. It will be an important companion for any experimentalist interesting in studying this protein family in their cell or organism model system. Focuses on intermediate filaments, including the latest information Provides an up-to-date understanding of the field Contains contributions from the major scientists working and publishing in the field

---

Book Detail:
Author: M. Bishr Omary
Publisher: Gulf Professional Publishing
ISBN: 9780125641739
Size: 72.92 MB
Format: PDF, ePub, Docs
Release Date: 2004-12-02
Category: Science
Language: en
View: 2402
Status: Available

Get Book
Book Description
Download PDF Intermediate Filament Cytoskeleton eBook. You can read online on your kindle, Android, iPhone, iPad. Intermediate filaments are a large family of proteins that are the cytoskeletal elements involved in a number of skin, liver, neuromuscular, cardiac, eye and hair diseases. Intermediate filament genes are regulated in a tissue-and cell type-specific manner and their polymerized protein products protects the cells and tissue they are part of against a variety of mechanical and nonmechanical stresses. This book provides a comprehensive resource of methodology essentials, describing a variety of essential tools and assays for studying intermediate filaments. The book provides user-friendly advice and protocols covering all aspects of intermediate filaments including protein isolation and structure, protein and gene regulation, relationship to disease and apoptosis, and associated proteins. Both mammalian and non-mammalian systems and animal models are covered, making this book a must-have for any investigator wishing to study IF genes or their protein products. * Covers intermediate filaments from crystallography, protein chemistry, cell and molecular biology, microrheology, gene regulation, to animal models and human disease * Practical and user-friendly with detailed "how-to-protocols and "tricks of the trade" * Includes detailed tables of useful reagents, vendors and web links

---

Book Detail:
Author: P. Traub
Publisher: Springer Science & Business Media
ISBN: 3642702309
Size: 46.37 MB
Format: PDF, ePub
Release Date: 2012-12-06
Category: Science
Language: en
View: 3876
Status: Available

Get Book
Book Description
Download PDF Intermediate Filaments eBook. You can read online on your kindle, Android, iPhone, iPad. Research on cytoskeletal elements of eukaryotic cells has been expand ing explosively during the past 5 to 10 years. Due largely to the employment of electron and immunofluorescent microscopy, significant results have been obtained which have provided interesting new insights into the dynamics of nucleated cells at the structural, physiological, as well as developmental levels. While a substantial amount of knowledge has accumulated on the function of microfilaments and microtubules, the roles of the third major class of cytoskeletal structures in vertebrate cells, the intermediate filaments, have largely resisted clarification. The investigation of cultured cells and of tissues from various developmental stages has furnished a host of information on the inter-and intracellular distribution of the different types of intermediate filaments and led to the contention that they have a structural and organizing function in the cytoplasm of vertebrate cells. However, the results of recent experimen that vertebrate cells can function perfectly in the tation have shown complete absence of cytoplasmically extended intermediate filament meshworks. It is legitimate to suppose, therefore, that their function in vertebrate cells is much more subtle and complex than generally presumed. Our interest in the structure and function of intermediate filament proteins was initiated approximately 7 years ago while working on the regulation of macromolecular synthesis in picornavirus-infected mam malian cells. In attempts to demonstrate virus-induced changes in the nuclear protein components of the host cells, the nonionic detergent extraction method was used to purify nuclei.

---

Book Detail:
Author: Jesus Paramio
Publisher: Springer Science & Business Media
ISBN: 0387337814
Size: 59.74 MB
Format: PDF, Kindle
Release Date: 2007-06-07
Category: Science
Language: en
View: 679
Status: Available

Get Book
Book Description
Download PDF Intermediate Filaments eBook. You can read online on your kindle, Android, iPhone, iPad. Intermediate Filaments focuses on desmin and other intermediate filaments in disease and health. This new volume will serve as a resource for graduate students and researchers in the field.

---

Book Detail:
Author:
Publisher: Academic Press
ISBN: 0128034904
Size: 70.90 MB
Format: PDF, Mobi
Release Date: 2016-01-14
Category: Medical
Language: en
View: 4121
Status: Available

Get Book
Book Description
Download PDF Intermediate Filament Associated Proteins eBook. You can read online on your kindle, Android, iPhone, iPad. Intermediate Filament Associated Proteins, the latest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in intermediate filament associated proteins and contains sections on such topics as lamin-associated proteins, intermediate filament-associated proteins and plakin, and other cytoskeletal cross-linkers. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods in intermediate filament associated proteins and contains sections on such topics as lamin-associated proteins, intermediate filament-associated proteins and plakin, and other cytoskeletal cross-linkers

---

Book Detail:
Author:
Publisher: Elsevier
ISBN: 9780080469393
Size: 70.37 MB
Format: PDF
Release Date: 2011-09-02
Category: Science
Language: en
View: 7706
Status: Available

Get Book
Book Description
Download PDF Aspects Of The Cytoskeleton eBook. You can read online on your kindle, Android, iPhone, iPad. This volume provides an overview of the cytoskeleton particularly on the fundamental role the cytoskeleton plays in the regulation of cell structure and function. This book represents new trends in cytoskeletal research that go beyond the traditional approach of identifying new proteins in the cytoskeleton, but actually define how these proteins interact with signaling pathways. While the major emphasis in this volume remains on the microfilament structure, some discussion has been included in this volume to illustrate the similarities and differences between the three cytoskeletal elements namely the actin microfilament, the intermediate filaments and the microtubules.

---

Book Detail:
Author: Normand Marceau
Publisher: Biota Publishing
ISBN: 1615045414
Size: 50.18 MB
Format: PDF, Mobi
Release Date: 2014-06-01
Category: Science
Language: en
View: 3261
Status: Available

Get Book
Book Description
Download PDF Intermediate Filaments eBook. You can read online on your kindle, Android, iPhone, iPad. Intermediate filaments (IFs), in concert with microfilaments (MFs) and microtubules (MTs), form the cytoskeleton, and each of these fibrillar networks exhibits rather unique structural and functional characteristics. Intermediate filaments were discovered in eukaryotic cells in the late 1960s, and their name comes from the fact that their diameter is intermediate between MFs and MTs. In contrast to the latter, IFs constitute a network that extends from the nuclear envelope throughout the cytoplasm, and in many cases, interact with cell surface domains involved in cell-cell and cell- matrix interactions. Several key features of their expression, assembly, structure and dynamics are highlighted in this eBook. For instance, IF proteins are encoded by several genes, which are classified into six types reflecting the tissues (cells) of origin. Moreover, IF proteins contain a conserved central α-helical (rod) domain flanked by N-terminal (head) and C-terminal (tail) globular domains that enables assembly of fibrous IFs exhibiting a tripartite structure. Although the rod domain is responsible for the formation of the coiled-coil framework and yields the main driving force during the IF protein assembly, the head and tail domains contribute to most of the structural heterogeneity of IF organization and undergo several types of post-translational modifications. Furthermore, the development of gene targeting methods to genetically knockout the expression of the IF genes in mice has uncovered the mechanical versus non-mechanical features of the IF networks, namely, their involvement in cell response to diverse forms of stress, growth stimulation, migration, or death insults. Finally, there is accumulating evidence revealing that the tissue and cell-type expression of IF genes reflects itself in the presence of causal or predisposition mutations responsible for numerous human tissue-specific diseases, known as IF-pathies. Table of Contents: List of Abbreviations / Introduction / IFs as a Multigene Family of Filamentous Proteins / Nuclear Lamina / IF Functional Interplay with Cell Surface Domains and Organelles / IFs and Cell Specialization / IF Relevance to Human Diseases / Conclusion / References / Author Biographies

---

Book Detail:
Author: Bruce Alberts
Publisher:
ISBN: 9780815332183
Size: 37.24 MB
Format: PDF, Kindle
Release Date: 2004
Category: Cells
Language: en
View: 6763
Status: Available

Get Book
Book Description
Download PDF Molecular Biology Of The Cell eBook. You can read online on your kindle, Android, iPhone, iPad.

---

Book Detail:
Author: Manfred Schliwa
Publisher: Springer Science & Business Media
ISBN: 3709176670
Size: 54.40 MB
Format: PDF, ePub, Mobi
Release Date: 2012-12-06
Category: Science
Language: en
View: 3778
Status: Available

Get Book
Book Description
Download PDF The Cytoskeleton eBook. You can read online on your kindle, Android, iPhone, iPad. The term cytoskeleton has become firmly established in today's scientific vocabulary. Indeed, it is difficult to believe that only ten years ago, it was virtually non-existent. Since then, the modern field of research on the structural organization of the cytoplasm has turned into one of the most productive and rapidly expanding research areas in Cell Biology today. Considerable progress has been made towards the identification of the various structural components of the cytoskeleton and their interactions with one another and with membranes. The first attempts to understand, in molecular terms, complex cellular processes such as shape changes, locomotion, division, and organelle movements have been made. And it is now apparent that the cytoskeleton has impact on other biological processes such as the control of gene expression, protein synthesis, cell cycle regulation, and development. This monograph outlines the basic properties of the major components of the polymeric filament networks and their interactions and associations. Wherever possible, emphasis is placed on more recent references. Any attempt to cover a research field this complex in an introductory mono graph is, by necessity, fragmentary, and oversights or omissions are inevitable. I wish to apologize in advance to all those colleagues who feel that their work is not adequately represented.

---

Book Detail:
Author: Thomas Dean Pollard
Publisher:
ISBN: 9781621820161
Size: 18.86 MB
Format: PDF, ePub, Docs
Release Date: 2017
Category: Cell membranes
Language: en
View: 7356
Status: Available

Get Book
Book Description
Download PDF The Cytoskeleton eBook. You can read online on your kindle, Android, iPhone, iPad. The cytoskeleton is the intracellular filament system that controls the morphology of a cell, allows it to move, and provides trafficking routes for intracellular transport. It comprises three major filament systems-actin, microtubules, and intermediate filaments-along with a host of adaptors, regulators, molecular motors, and additional structural proteins. This textbook presents a comprehensive and up-to-date view of the cytoskeleton, cataloguing its many different components and explaining how they are functionally integrated in different cellular processes. It starts by laying out the basic molecular hardware, before describing in detail how these components are assembled in cells and linked to neighboring cells and the extracellular matrix to maintain tissue architecture. It then surveys the roles of the cytoskeleton in processes such as intracellular transport, cell motility, signal transduction, and cell division. The book is thus essential reading for students learning about intracellular structure. It also represents a vital reference for all cell and developmental biologists working in this field.

---

Book Detail:
Author: Nalini Chandar
Publisher: Lippincott Williams & Wilkins
ISBN: 1469816652
Size: 69.86 MB
Format: PDF, ePub, Mobi
Release Date: 2012-08-14
Category: Medical
Language: en
View: 3874
Status: Available

Get Book
Book Description
Download PDF Cell And Molecular Biology eBook. You can read online on your kindle, Android, iPhone, iPad. Lippincott's Illustrated Reviews: Cell and Molecular Biology offers a highly visual presentation of essential cell and molecular biology, focusing on topics related to human health and disease. This new addition to the internationally best-selling Lippincott's Illustrated Reviews Series includes all the popular features of the series: an abundance of full-color annotated illustrations, expanded outline format, chapter summaries, review questions, and case studies that link basic science to real-life clinical situations. The book can be used as a review text for a stand-alone cell biology course in medical, health professions, and upper-level undergraduate programs, or in conjunction with Lippincott's Illustrated Reviews: Biochemistry for integrated courses. A companion Website features the fully searchable online text, an interactive Question Bank for students, and an Image Bank for instructors to create PowerPoint® presentations.

---

Book Detail:
Author: Heide Schatten
Publisher: Springer
ISBN: 1493929046
Size: 71.56 MB
Format: PDF
Release Date: 2015-08-21
Category: Science
Language: en
View: 2017
Status: Available

Get Book
Book Description
Download PDF The Cytoskeleton In Health And Disease eBook. You can read online on your kindle, Android, iPhone, iPad. This volume addresses the structural and functional roles of the cytoskeleton and its dysfunctions which often lead to disease. It provides thorough discussion of microtubules, microfilaments, intermediate filaments, and cytoskeletal functions and dysfunctions in different organ systems. Comprehensive yet concise. The Cytoskeleton In Health And Disease presents cutting-edge discoveries balanced with background information and highlights the new aspects of the research and its impact on the design of new strategies or the identification of new targets for therapeutic intervention. There is a significant need for a book on this topic, as interest in the cytoskeleton continues to grow as causes and cures for cytoskeletal diseases are further explored in biomedical research. This book is essential reading for scientists, students, and teachers interested in expanding their knowledge related to the cytoskeleton. New researchers entering the field will find classic and well as contemporary information not easily found in the current literature or internet resources.

---

Book Detail:
Author: David A. D. Parry
Publisher: R G Landes Company
ISBN: 9781570591204
Size: 10.18 MB
Format: PDF, Mobi
Release Date: 1995
Category: Science
Language: en
View: 7354
Status: Available

Get Book
Book Description
Download PDF Intermediate Filament Structure eBook. You can read online on your kindle, Android, iPhone, iPad. Covers the structure and role of intermediate filament (IF) proteins in a variety of cell types. The text examines the expression of IF proteins, the hierarchical assembly of those proteins into molecules, oligomers, protofilaments, protofilbrils and intact IF.

---

Book Detail:
Author: George Plopper
Publisher: Jones & Bartlett Publishers
ISBN: 1284047628
Size: 38.50 MB
Format: PDF, ePub
Release Date: 2014-10-21
Category: Medical
Language: en
View: 5029
Status: Available

Get Book
Book Description
Download PDF Principles Of Cell Biology eBook. You can read online on your kindle, Android, iPhone, iPad. Written for undergraduate cell biology courses, Principles of Cell Biology, Second Edition provides students with the formula for understanding the fundamental concepts of cell biology. This practical text focuses on the underlying principles that illustrate both how cells function as well as how we study them. It identifies 10 specific principles of cell biology and devotes a separate chapter to illustrate each. The result is a shift away from the traditional focus on technical details and towards a more integrative view of cellular activity that is flexible and can be tailored to suit students with a broad range of backgrounds.

---

Book Detail:
Author: Terence Allen
Publisher: OUP Oxford
ISBN: 0191620262
Size: 44.13 MB
Format: PDF, ePub
Release Date: 2011-09-29
Category: Science
Language: en
View: 1546
Status: Available

Get Book
Book Description
Download PDF The Cell A Very Short Introduction eBook. You can read online on your kindle, Android, iPhone, iPad. All living things on Earth are composed of cells. A cell is the simplest unit of a self-contained living organism, and the vast majority of life on Earth consists of single-celled microbes, mostly bacteria. These consist of a simple 'prokaryotic' cell, with no nucleus. The bodies of more complex plants and animals consist of billions of 'eukaryotic' cells, of varying kinds, adapted to fill different roles - red blood cells, muscle cells, branched neurons. Each cell is an astonishingly complex chemical factory, the activities of which we have only begun to unravel in the past fifty years or so through modern techniques of microscopy, biochemistry, and molecular biology. In this Very Short Introduction, Terence Allen and Graham Cowling describe the nature of cells - their basic structure, their varying forms, their division, their differentiation from initially highly flexible stem cells, their signalling, and programmed death. Cells are the basic constituent of life, and understanding cells and how they work is central to all biology and medicine. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.

---

Book Detail:
Author: Dennis Bray
Publisher: Garland Science
ISBN: 9780815332824
Size: 33.21 MB
Format: PDF
Release Date: 2001
Category: Cells
Language: en
View: 4402
Status: Available

Get Book
Book Description
Download PDF Cell Movements eBook. You can read online on your kindle, Android, iPhone, iPad. This book vividly describes how complex and integrated movements can arise from the properties and behaviors of biological molecules. It provides a uniquely integrated account in which the latest findings from biophysics and molecular biology are put into the context of living cells. This second edition is updated throughout with recent advances in the field and has a completely revised and redrawn art program. The text is suitable for advanced undergraduates, graduate students, and for professionals wishing for an overview of this field.

---

Book Detail:
Author: H.L. Granzier
Publisher: Springer Science & Business Media
ISBN: 1461542677
Size: 67.11 MB
Format: PDF, Kindle
Release Date: 2012-12-06
Category: Science
Language: en
View: 3950
Status: Available

Get Book
Book Description
Download PDF Elastic Filaments Of The Cell eBook. You can read online on your kindle, Android, iPhone, iPad. Elastic filaments refer mainly to titin, the largest of all known proteins. Titin was discovered initially in muscle cells, where it interconnects the thick filament with the Z-line. Titin forms a molecular spring that is responsible for maintaining the structural integrity of contracting muscle, ensuring efficient muscle contraction. More recently, it has become clear that titin is not restricted to muscle cells alone. For example, titin is found in chromosomes of neurons and also in blood platelets. This topic is fast becoming a focal point for research in understanding viscoelastic properties at the molecular, cellular, and tissue levels. In titin may lie a generic basis for biological viscoelasticity. It has become clear that titin may hold the key to certain clinical anomalies. For example, it is clear that titin-based ventricular stiffness is modulated by calcium and that titin is responsible for the altered stiffness in cardiomyopathies. It is also clear from evidence from a group of Finnish families that titin mutations may underlie some muscular dystrophies and that with other mutations chromatids fail to separate during mitosis. Thus, it is clear that this protein will have important clinical implications stemming from its biomechanical role. One aspect of this field is the bringing together of bioengineers with clinical researchers and biologists. Genetic and biochemical aspects of titin-related proteins are being studied together with front-line engineering approaches designed to measure the mechanics of titin either in small aggregates or in single molecules.

---

Book Detail:
Author: David A.D. Parry
Publisher: Springer
ISBN: 9783540590804
Size: 57.25 MB
Format: PDF, ePub, Docs
Release Date: 1995-05-24
Category: Science
Language: en
View: 7306
Status: Available

Get Book
Book Description
Download PDF Intermediate Filament Structure eBook. You can read online on your kindle, Android, iPhone, iPad. This book is about the structure and role of intermediate filament (IF) proteins in a diversity of cell types, including neurones and those from the epithelium. Part of the text is devoted to a discussion of the expression of IF proteins, the hierarchical assembly of those proteins into molecules, oligomers, protofilaments, protofibrils and finally intact IF, and the spatial organization of bundles of these IF within the cytoplasm and the nuclear lamina. IF-associated proteins (IFAPs), which may modulate aggregation or function, are also considered in this context. The final topic that is considered centers on the recent and exciting developments in the area of skin diseases, which have been related directly to IF pathology and to mutation in specific keratin chains.

---