Book Detail:
Author: A.D. Bershadsky
Publisher: Springer Science & Business Media
ISBN: 1468452789
Size: 13.41 MB
Format: PDF, Kindle
Release Date: 2012-12-06
Category: Science
Language: en
View: 6341
Status: Available

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Book Description
Download PDF Cytoskeleton eBook. You can read online on your kindle, Android, iPhone, iPad. This book, like other monographs of the Cellular Organelles series, is not a comprehensive review, but an introduction to the study of cytoskeleton. Accordingly, we describe only the main facts and concepts related to cyto skeleton. Needless to say, selection and interpretation was influenced by the personal interests and opinions of the authors, although we attempted to be as fair as possible. We wished to familiarize the reader not only with well established facts, but with current unsolved problems. Therefore, the words "possibly," "maybe," "not known," and "not clear" are much more frequent in this text than in many others. In accordance with the style of the series, relatively short lists of addi tional readings are given at the end of each chapter; these lists contain mostly the recent reviews and a few original papers describing certain phenomena in detail. Few references are cited in the text; these citations are given to help the reader find the source of certain new data and theories, which are not discussed at length in the reviews. In contrast, many well-established facts and widely known theories are not cited.

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Book Detail:
Author: Heide Schatten
Publisher: Springer
ISBN: 1493929046
Size: 74.40 MB
Format: PDF, Kindle
Release Date: 2015-08-21
Category: Science
Language: en
View: 1500
Status: Available

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Book Description
Download PDF The Cytoskeleton In Health And Disease eBook. You can read online on your kindle, Android, iPhone, iPad. This volume addresses the structural and functional roles of the cytoskeleton and its dysfunctions which often lead to disease. It provides thorough discussion of microtubules, microfilaments, intermediate filaments, and cytoskeletal functions and dysfunctions in different organ systems. Comprehensive yet concise. The Cytoskeleton In Health And Disease presents cutting-edge discoveries balanced with background information and highlights the new aspects of the research and its impact on the design of new strategies or the identification of new targets for therapeutic intervention. There is a significant need for a book on this topic, as interest in the cytoskeleton continues to grow as causes and cures for cytoskeletal diseases are further explored in biomedical research. This book is essential reading for scientists, students, and teachers interested in expanding their knowledge related to the cytoskeleton. New researchers entering the field will find classic and well as contemporary information not easily found in the current literature or internet resources.

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Book Detail:
Author:
Publisher: Elsevier
ISBN: 9780080469393
Size: 36.56 MB
Format: PDF, ePub, Docs
Release Date: 2011-09-02
Category: Science
Language: en
View: 3863
Status: Available

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Book Description
Download PDF Aspects Of The Cytoskeleton eBook. You can read online on your kindle, Android, iPhone, iPad. This volume provides an overview of the cytoskeleton particularly on the fundamental role the cytoskeleton plays in the regulation of cell structure and function. This book represents new trends in cytoskeletal research that go beyond the traditional approach of identifying new proteins in the cytoskeleton, but actually define how these proteins interact with signaling pathways. While the major emphasis in this volume remains on the microfilament structure, some discussion has been included in this volume to illustrate the similarities and differences between the three cytoskeletal elements namely the actin microfilament, the intermediate filaments and the microtubules.

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Book Detail:
Author: Manfred Schliwa
Publisher: Springer Science & Business Media
ISBN: 3709176670
Size: 71.60 MB
Format: PDF, ePub, Mobi
Release Date: 2012-12-06
Category: Science
Language: en
View: 5894
Status: Available

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Book Description
Download PDF The Cytoskeleton eBook. You can read online on your kindle, Android, iPhone, iPad. The term cytoskeleton has become firmly established in today's scientific vocabulary. Indeed, it is difficult to believe that only ten years ago, it was virtually non-existent. Since then, the modern field of research on the structural organization of the cytoplasm has turned into one of the most productive and rapidly expanding research areas in Cell Biology today. Considerable progress has been made towards the identification of the various structural components of the cytoskeleton and their interactions with one another and with membranes. The first attempts to understand, in molecular terms, complex cellular processes such as shape changes, locomotion, division, and organelle movements have been made. And it is now apparent that the cytoskeleton has impact on other biological processes such as the control of gene expression, protein synthesis, cell cycle regulation, and development. This monograph outlines the basic properties of the major components of the polymeric filament networks and their interactions and associations. Wherever possible, emphasis is placed on more recent references. Any attempt to cover a research field this complex in an introductory mono graph is, by necessity, fragmentary, and oversights or omissions are inevitable. I wish to apologize in advance to all those colleagues who feel that their work is not adequately represented.

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Book Detail:
Author: Jerry Shay
Publisher: Springer
ISBN: 9781468445947
Size: 27.13 MB
Format: PDF, Kindle
Release Date: 2013-10-21
Category: Medical
Language: en
View: 4066
Status: Available

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Book Description
Download PDF The Cytoskeleton eBook. You can read online on your kindle, Android, iPhone, iPad. The preceding volumes of Cell and Muscle Motility have focused on various aspects of motile systems in both muscle and non muscle cells. These essays have been critical reviews on topics of current interest and, hopefully, have provided a base from which future investigations may develop. During the past decade, however, much attention in the fields of biochemistry and cell biology has focused on motile systems in non muscle cells. Our current under standing of the three-dimensional organization of the cytoplasm involve three major fibrous proteins which are collectively known as the cytoskeletal system. These polymorphic cytoskeletal proteins are microtubules (25-nm diameter), microfilaments (6-nm diameter), and intermediate filaments (lO-nm diame ter). Microtubules consist of tubulin and several well-characterized micro tubule associated proteins (MAPs) including MAP , MAP , tau, and others. l 2 Microfilaments consist of actin and associate with actin-binding proteins in cluding a-actinin, filamin, myosin, tropomyosin, vinculin, and others. Inter mediate filaments (lO-nm filaments) consist of at least five different tissue specific classes, including desmin or skeletin (muscle), prekeratin (epithelial), vimentin (mesenchymal), neurofilament (nerve), and glial acidic fibrillary protein (astrocytes). These major fibrous proteins apparently interact with each other as well as other cytoplasmic components and appear to be inti mately associated with such biological processes as cell shape changes, growth, motility, secretion, cell division, and uptake of materials from the exterior of the cell.

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Book Detail:
Author: Kermit L. Carraway
Publisher: Oxford University Press, USA
ISBN:
Size: 29.29 MB
Format: PDF, Mobi
Release Date: 1992
Category: Cytology
Language: en
View: 2087
Status: Available

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Book Description
Download PDF The Cytoskeleton eBook. You can read online on your kindle, Android, iPhone, iPad. Cytoskeletal research has undergone rapid progress in recent years and is currently an area of research activity. This book provides a wealth of methods and expert advice for investigating the cytoskeletal elements of eukaryotic cells. It focuses on the dynamic and functional aspects of the three major systems of the cytoskeleton--microfilaments, intermediate filaments and microtubules, and their interactions with their associate proteins. Detailed experimental protocols for state-of-the-art techniques are given throughout, and emphasis is placed on recent advances in areas such as video microscopy, molecular biology, immunological analysis, and microchemistry of proteins. This comprehensive volume will be useful to both experienced and novice researchers who wish to apply the technologies available for the study of these important components of eukaryotic cell structure.

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Book Detail:
Author: Jonathan M. Lee
Publisher: Biota Publishing
ISBN: 1615043896
Size: 49.95 MB
Format: PDF, Docs
Release Date: 2013-06-01
Category: Science
Language: en
View: 4390
Status: Available

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Book Description
Download PDF The Actin Cytoskeleton And The Regulation Of Cell Migration eBook. You can read online on your kindle, Android, iPhone, iPad. The mammalian cytoskeleton is an internal framework of actin, tubulin, and intermediate filament proteins. Proteins of these three classes assemble non-covalently into filamentous polymers that support the structural integrity of the relatively fragile lipid plasma membrane. In addition, cytoskeletal polymers provide the mechanical strength that hold a cell together and anchor it to its growth substrate. The cytoskeleton must also have the capacity for rapid and substantial remodeling and provide the motive and tractor force necessary to drive motility. As such, the cytoskeleton has a functional duality: sufficiently rigid to prevent plasma membrane deformation but pliable enough to allow for cytokinesis; sufficiently adhesive to allow for traction but dynamic enough to allow movement from one place to another. A major research challenge in cytoskeleton biology is to understand how cytoskeletal proteins assemble and dissemble in support of physiological processes. This chapter will focus on the role of the actin cytoskeleton in cell migration. More specifically, we will focus on the actin cytoskeleton of vertebrate cells. Table of Contents: Introduction / The Fundamentals of Actin Polymerization / Accessory Proteins Regulate Actin Polymerization and Assembly / Cellular Actin Structure / Cell Migration / Summary of Cell Migration / References / Author Biography

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Book Detail:
Author: Jose C. Jimenez-Lopez
Publisher: BoD – Books on Demand
ISBN: 9535131699
Size: 42.84 MB
Format: PDF, Mobi
Release Date: 2017-05-17
Category: Science
Language: en
View: 1016
Status: Available

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Book Description
Download PDF Cytoskeleton eBook. You can read online on your kindle, Android, iPhone, iPad. The cytoskeleton is a highly dynamic intracellular platform constituted by a three-dimensional network of proteins responsible for key cellular roles as structure and shape, cell growth and development, and offering to the cell with "motility" that being the ability of the entire cell to move and for material to be moved within the cell in a regulated fashion (vesicle trafficking). The present edition of Cytoskeleton provides new insights into the structure-functional features, dynamics, and cytoskeleton's relationship to diseases. The authors' contribution in this book will be of substantial importance to a wide audience such as clinicians, researches, educators, and students interested in getting updated knowledge about molecular basis of cytoskeleton, such as regulation of cell vital processes by actin-binding proteins as cell morphogenesis, motility, their implications in cell signaling, as well as strategies for clinical trial and alternative therapies based in multitargeting molecules to tackle diseases, that is, cancer.

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Book Detail:
Author: J.E. Hesketh
Publisher: Elsevier
ISBN: 9780080530192
Size: 25.23 MB
Format: PDF
Release Date: 1996-06-25
Category: Science
Language: en
View: 459
Status: Available

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Book Description
Download PDF Cytoskeleton In Specialized Tissues And In Pathological States eBook. You can read online on your kindle, Android, iPhone, iPad. This volume deals with aspects of the cytoskeleton in different cell types and also describe examples of changes in the cytoskeleton which occur during various pathological states. These studies bring the exciting area of cytoskeleton research into the domain of medical science.

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Book Detail:
Author: A. B. Fulton
Publisher: Alice Fulton
ISBN: 9780412255106
Size: 68.62 MB
Format: PDF, Docs
Release Date: 1984-09-27
Category: Juvenile Nonfiction
Language: en
View: 1475
Status: Available

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Book Description
Download PDF The Cytoskeleton Cellular Architecture And Choreography eBook. You can read online on your kindle, Android, iPhone, iPad. The student of biological science in his final years as an undergraduate and his first years as a graduate is expected to gain some familiarity with current research at the frontiers of his discipline. New research work is published in a perplexing diversity of publications and is inevitably con cerned with the minutiae of the subject. The sheer number of research journals and papers also causes confusion and difficulties of assimilation. Review articles usually presuppose a background knowledge of the field and are inevitably rather restricted in scope. There is thus a need for short but authoritative introductions to those areas of modern biological research which are either not dealt with in standard introductory text books or are not dealt with in sufficient detail to enable the student to go on from them to read scholarly reviews with profit. This series of books is designed to satisfy this need. The authors have been asked to produce a brief outline of their subject assuming that their readers will have read and remembered much of a standard introductory textbook of biology. This outline then sets out to provide by building on this basis, the conceptual framework within which modern research work is progressing and aims to give the reader an indication of the problems, both conceptual and practical, which must be overcome if progress is to be maintained.

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Book Detail:
Author: Ralph A. Nixon
Publisher: Springer Science & Business Media
ISBN: 1441967877
Size: 63.79 MB
Format: PDF, Docs
Release Date: 2011-02-04
Category: Medical
Language: en
View: 3013
Status: Available

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Book Description
Download PDF Cytoskeleton Of The Nervous System eBook. You can read online on your kindle, Android, iPhone, iPad. This monograph begins with a general description of the cytoskeleton in axonal development and pathology and then moves to more detailed descriptions of particular components, including microtubules and associated proteins, neurofilaments and interacting proteins, actin and its binding proteins, and glial fibrillary acidic protein. The later chapters focus on the functional significance of the neuronal cytoskeleton in axonal transport and its regulation in health and disease states. The Cytoskeleton of the Nervous System will encourage further development of unifying principles and stimulate new conceptual and technical approaches toward a better understanding of cytoskeleton functions in health and disease.

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Book Detail:
Author: Thomas W. Clarkson
Publisher: Springer Science & Business Media
ISBN: 1461321611
Size: 25.33 MB
Format: PDF, ePub
Release Date: 2012-12-06
Category: Science
Language: en
View: 7431
Status: Available

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Book Description
Download PDF The Cytoskeleton eBook. You can read online on your kindle, Android, iPhone, iPad. This book is based on reviews and research presentations given at the 16th Rochester International Conference on Environmental Toxicity, entitled liThe Cytoskeleton: A Target for Toxic Agents," held on June 4, 5 and 6 in 1984. The conference provided an in-depth discussion of the effects a~d mechanism of action of some toxic agents on the cytoskeleton. Mamma"lian and other eukaryotic cells contain protein networks within the cytoplasm comprised of microfilaments, intermediate Hlaments and microtubules. These components of the cytoskeleton playa key role in cell shape, motility, intracellular organization and transport, and cell division. Furthermore, the cytoskeleton, via associations with the cell membrane, appears to function in intracellular communication and cellular responses to membrane events. Because of the complex functional roles of the cytoskeleton which vary with cell type, degree of differentiation, and cell cycle, its disruption may result in a variety of cellular changes. This expanding field in cell biology has already attracted the interest of toxicologists and environmental health scientists as a potentially fruitful area of research. Indeed, there is mounting evidence that certain toxic and chemotherapeutic compounds, as well as physical agents such as radiation and hydrostatic pressure, disrupt the normal structure and function of the cytoskeleton. This may be an important step in the overall expression of their action. It was, therefore, an opportune time to hold a conference to encourage the development of this area of toxicology and to suggest directions for future research.

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Book Detail:
Author: Terence M. Preston
Publisher: Blackie Academic and Professional
ISBN:
Size: 62.22 MB
Format: PDF
Release Date: 1990
Category: Cells
Language: en
View: 7341
Status: Available

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Book Description
Download PDF The Cytoskeleton And Cell Motility eBook. You can read online on your kindle, Android, iPhone, iPad.

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Book Detail:
Author: J.W. Shay
Publisher: Springer
ISBN:
Size: 78.58 MB
Format: PDF, Docs
Release Date: 1986-05-31
Category: Science
Language: en
View: 1556
Status: Available

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Book Description
Download PDF Cell And Molecular Biology Of The Cytoskeleton eBook. You can read online on your kindle, Android, iPhone, iPad. Cell and Molecular Biology of the Cytoskeleton focuses on the three major fibrous proteins in the cytoplasm that are collectively known as the cytoskeletal sys­ tem. These polymorphic cytoskeletal proteins are microtubules (25-nm diam­ eter), microfilaments (6-nm diameter), and intermediate filaments (l O-nm diameter). Microtubules consist of tubulin and several well-characterized mi­ crotubule-associated proteins (MAPs) such as MAPl, MAP2, and tau. Micro­ filaments consist of actin and associate with actin-binding proteins, including alpha-actinin, filamin, myosin, tropomyosin, vinculin, and others. Intermedi­ ate filaments consist of at least five different tissue-specific classes, including desmin or skeletin (muscle), prekeratin (epithelial), vimentin (mesenchymal), neurofilament (nerve), and glial acidic fibrillary protein (astrocytes). In this volume distinguished researchers in the field cover the interaction of these fibrous proteins, not only with each other and other cytoplasmic components, but also with such biological processes as cell shape changes, growth, motility, secretion, and division. These comprehensive reviews ex­ plore the cytoskeleton's molecular, biochemical, and structural properties with an emphasis on their manifestation in the living cell.

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Book Detail:
Author: Gerhard Isenberg
Publisher: Springer Science & Business Media
ISBN: 364279632X
Size: 58.67 MB
Format: PDF, Mobi
Release Date: 2012-12-06
Category: Science
Language: en
View: 6221
Status: Available

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Book Description
Download PDF Cytoskeleton Proteins eBook. You can read online on your kindle, Android, iPhone, iPad. The standard protocols for the purification of all known cytoskeleton proteins are presented in this manual. Proteins are listed alphabetically and each protocol follows a common format. Thus, the manual provides a quick and easy reference to all relevant procedures for cytoskeleton protein purification. The isolation procedure for each protein is shown in a clear flowchart, while the source of the protein, equipment and material needed, a list of suppliers, standard references, accession No. of sequences as well as further relevant facts and practical tips are given on a separate page.

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Book Detail:
Author: Gáspár Jékely
Publisher: Springer Science & Business Media
ISBN: 038774021X
Size: 73.56 MB
Format: PDF, ePub, Docs
Release Date: 2008-09-08
Category: Science
Language: en
View: 4594
Status: Available

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Book Description
Download PDF Eukaryotic Membranes And Cytoskeleton eBook. You can read online on your kindle, Android, iPhone, iPad. The presence/absence of gene families with central roles in endomembrane and cytoskeleton dynamics in a variety of eukaryotic taxa and an understanding of eukaryote phylogeny allow the cellular machineries present in the last common ancestor of eukaryotes to be accurately reconstructed. Such a reconstruction is fundamental in order to understand eukaryotic diversification, since this is the ancestral cell from which all diversity arose. This book discusses the evolutionary origin and diversification of eukaryotic endomembranes and cytoskeleton from a cell biological and comparative genomic perspective.

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Book Detail:
Author: Ray H. Gavin
Publisher: Springer Science & Business Media
ISBN: 1592590519
Size: 24.30 MB
Format: PDF, ePub, Docs
Release Date: 2008-02-03
Category: Science
Language: en
View: 5670
Status: Available

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Book Description
Download PDF Cytoskeleton Methods And Protocols eBook. You can read online on your kindle, Android, iPhone, iPad. Over the past two decades experimental studies have solidified the int- pretation of the cytoskeleton as a highly dynamic network of microtubules, actin microfilaments, intermediate filaments, and myosin filaments. Rather than a network of disparate fibers, these polymers are often interconnected and display synergy, which is the combined action of two or more cytoskeletal polymers to achieve a specific cellular structure or function. Cross-commu- cation among cytoskeletal polymers is thought to be achieved through cytoskeletal polymer accessory proteins and molecular motors that bind two or more cytoskeletal polymers. Development of the modern concept of the cytoskeleton is a direct o- growth of advances in experimental tools and reagents that are available to cell and molecular biologists. Technological advances and refinements in cell imaging have made it possible to selectively image a single cytoskeletal po- mer and monitor its dynamics through the use of fluorescence probes in vitro and in vivo. Two decades ago, cytoskeletal research was limited to a few perturbation reagents that included colchicine and cytochalasin. Today, the perturbation arsenal has expanded to a highly selective group of reagents that includes Taxol, nocodazole, benomyl, latrunculin, jasplakinolide, and such endogenous proteins as gelsolin. These reagents enable the investigator to selectively perturb or destroy a cytoskeletal polymer while leaving other cytoskeletal polymers intact. Site-specific monoclonal antibodies that target a specific cytoskeletal polymer have proven to be highly selective affinity tools for cytoskeletal research.

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Book Detail:
Author: Brigitte M. Jockusch
Publisher: Springer
ISBN: 9783319835037
Size: 37.93 MB
Format: PDF, Docs
Release Date: 2018-07-07
Category: Medical
Language: en
View: 2746
Status: Available

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Book Description
Download PDF The Actin Cytoskeleton eBook. You can read online on your kindle, Android, iPhone, iPad. Actin is one of the most abundant proteins and ubiquitously expressed in all eukaryotes. In recent years, the analysis of structure and function of such complexes has shed new light on actin's role in cellular and tissue morphogenesis, locomotion and various forms of intracellular motility, but also on its role in nuclear processes like chromatin architecture and transcription. Progress in understanding these different physiological phenomena, but also in unravelling the basis of actin-based pathophysiological processes has been made by combining video microscopy, molecular biology, genetics and biochemistry. Thus, the current research on actin, as ongoing in many international laboratories, is a "hot spot" in basic and translational research in life sciences. In this book on "The Actin Cytoskeleton", twelve internationally renowned authors present specific chapters that cover their recent work concerned with the various roles of actin mentioned above. This comprehensive volume is therefore an attractive handbook for teachers and students in many fields of medicine and pharmacology.

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Book Detail:
Author: Bo Liu
Publisher: Springer Science & Business Media
ISBN: 1441909877
Size: 69.88 MB
Format: PDF, Mobi
Release Date: 2010-11-23
Category: Science
Language: en
View: 1485
Status: Available

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Book Description
Download PDF The Plant Cytoskeleton eBook. You can read online on your kindle, Android, iPhone, iPad. Plant cells house highly dynamic cytoskeletal networks of microtubules and actin microfilaments. They constantly undergo remodeling to fulfill their roles in supporting cell division, enlargement, and differentiation. Following early studies on structural aspects of the networks, recent breakthroughs have connected them with more and more intracellular events essential for plant growth and development. Advanced technologies in cell biology (live-cell imaging in particular), molecular genetics, genomics, and proteomics have revolutionized this field of study. Stories summarized in this book may inspire enthusiastic scientists to pursue new directions toward understanding functions of the plant cytoskeleton. The Plant Cytoskeleton is divided into three sections: 1) Molecular Basis of the Plant Cytoskeleton; 2) Cytoskeletal Reorganization in Plant Cell Division; and 3) The Cytoskeleton in Plant Growth and Development. This book is aimed at serving as a resource for anyone who wishes to learn about the plant cytoskeleton beyond ordinary textbooks.

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Book Detail:
Author: Vaidurya Pratap Sahi
Publisher: Springer Nature
ISBN: 3030335283
Size: 78.67 MB
Format: PDF, ePub
Release Date: 2019-11-30
Category: Science
Language: en
View: 2181
Status: Available

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Book Description
Download PDF The Cytoskeleton eBook. You can read online on your kindle, Android, iPhone, iPad. This book focuses on the plant cytoskeleton and its various cross-talks with other cellular components leading to its role in plant growth and development. It not only allows the geometric and signaling dimensions of cells, but is also very important in physiological processes. The book discusses the recent studies showing the role of actin and microtubule cytoskeleton interactions in cell-wall assembly and dynamics. The authors examine the role of both microtubules in the mechanics of plant cells, and actin filaments in the motility of chloroplasts. Based on recent advances in the study of the acto-myosin complex using high-resolution microscopy, they propose a new model for intracellular transport in plants. Exploring an almost-forgotten field of bioelectricity in the context of the cytoskeleton, the book highlights connections between the dynamic actin filaments and the bioelectricity of membranes and demonstrates that the plant cytoskeleton is involved in the distribution of plant hormones. Lastly, it addresses the role of endomembrane -cytoskeleton interactions to show the importance of the cytoskeleton in organelle morphogenesis and cellular functions. Studies in various plant models have shown how the actin filament and microtubules control and coordinate plant cell growth and development. This book summarizes the mechanisms underlying these functions.

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