Book Detail:
Author: Anngrit Maria Lutz
Publisher:
ISBN:
Size: 18.26 MB
Format: PDF, ePub, Mobi
Release Date: 2020
Category:
Language: en
View: 1513
Status: Available

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Download PDF Effects Of Cell Stretch On The Keratin Intermediate Filament Cytoskeleton In A549 Lung Cells eBook. You can read online on your kindle, Android, iPhone, iPad.

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Book Detail:
Author: M. Bishr Omary
Publisher: Gulf Professional Publishing
ISBN: 9780125641739
Size: 17.79 MB
Format: PDF, Docs
Release Date: 2004-12-02
Category: Science
Language: zh-TW
View: 2916
Status: Available

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Download PDF Intermediate Filament Cytoskeleton eBook. You can read online on your kindle, Android, iPhone, iPad. Intermediate filaments are a large family of proteins that are the cytoskeletal elements involved in a number of skin, liver, neuromuscular, cardiac, eye and hair diseases. Intermediate filament genes are regulated in a tissue-and cell type-specific manner and their polymerized protein products protects the cells and tissue they are part of against a variety of mechanical and nonmechanical stresses. This book provides a comprehensive resource of methodology essentials, describing a variety of essential tools and assays for studying intermediate filaments. The book provides user-friendly advice and protocols covering all aspects of intermediate filaments including protein isolation and structure, protein and gene regulation, relationship to disease and apoptosis, and associated proteins. Both mammalian and non-mammalian systems and animal models are covered, making this book a must-have for any investigator wishing to study IF genes or their protein products. * Covers intermediate filaments from crystallography, protein chemistry, cell and molecular biology, microrheology, gene regulation, to animal models and human disease * Practical and user-friendly with detailed "how-to-protocols and "tricks of the trade" * Includes detailed tables of useful reagents, vendors and web links

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Book Detail:
Author: David A. D. Parry
Publisher: R G Landes Company
ISBN: 9781570591204
Size: 71.44 MB
Format: PDF, ePub, Docs
Release Date: 1995
Category: Science
Language: en
View: 5920
Status: Available

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Book Description
Download PDF Intermediate Filament Structure eBook. You can read online on your kindle, Android, iPhone, iPad. Covers the structure and role of intermediate filament (IF) proteins in a variety of cell types. The text examines the expression of IF proteins, the hierarchical assembly of those proteins into molecules, oligomers, protofilaments, protofilbrils and intact IF.

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Book Detail:
Author: Florian Lang
Publisher: S. Karger AG (Switzerland)
ISBN:
Size: 18.90 MB
Format: PDF, ePub
Release Date: 1998
Category: Cell Size
Language: en
View: 1297
Status: Available

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Book Description
Download PDF Cell Volume Regulation eBook. You can read online on your kindle, Android, iPhone, iPad. This volume presents a unique compilation of reviews on cell volume regulation in health and disease, with contributions from leading experts in the field. The topics covered include mechanisms and signaling of cell volume regulation and the effect of cell volume on cell function, with special emphasis on ion channels and transporters, kinases and gene expression. Several chapters elaborate on how cell volume regulatory mechanisms participate in the regulation of epithelial transport, urinary concentration, metabolism, migration, cell proliferation and apoptosis. Last but not least, this publication is an excellent guide to the role of cell volume in the pathophysiology of hypercatabolism, diabetes mellitus, brain edema, hemoglobinopathies, tumor growth and metastasis, to name just a few. Providing deeper insights into an exciting area of research which is also of clinical relevance, this publication is a valuable addition to the library of those interested in cell volume regulation.

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Book Detail:
Author: Vladimir A. Botchkarev
Publisher: Springer
ISBN: 3319167693
Size: 48.58 MB
Format: PDF, Mobi
Release Date: 2018-09-03
Category: Science
Language: en
View: 7772
Status: Available

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Book Description
Download PDF Epigenetic Regulation Of Skin Development And Regeneration eBook. You can read online on your kindle, Android, iPhone, iPad. This indispensable volume highlights recent studies identifying epigenetic mechanisms as essential regulators of skin development, stem cell activity and regeneration. Chapters are contributed by leading experts and promote the skin as an accessible model system for studying mechanisms that control organ development and regeneration. The timely discussions contained throughout are of broad relevance to other areas of biology and medicine and can help inform the development of novel therapeutics for skin disorders as well as new approaches to skin regeneration that target the epigenome. Part of the highly successful Stem Cells and Regenerative Medicine series, Epigenetic Regulation of Skin Development and Regeneration uncovers the fundamental significance of epigenetic mechanisms in skin development and regeneration, and emphasizes the development of new therapies for a number of skin disorders, such as pathological conditions of epidermal differentiation, pigmentation and carcinogenesis. At least six categories of researchers will find this book essential, including stem cell, developmental, hair follicle or molecular biologists, and gerontologists or clinical dermatologists.

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Book Detail:
Author: Kazuwa Nakao
Publisher: Springer
ISBN: 4431556516
Size: 75.20 MB
Format: PDF, ePub, Mobi
Release Date: 2015-10-13
Category: Medical
Language: en
View: 6782
Status: Available

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Book Description
Download PDF Innovative Medicine eBook. You can read online on your kindle, Android, iPhone, iPad. This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.

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Book Detail:
Author: Bup Wan Kim
Publisher: Springer
ISBN: 9811027234
Size: 80.64 MB
Format: PDF, ePub
Release Date: 2017-09-14
Category: Medical
Language: en
View: 3436
Status: Available

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Book Description
Download PDF Clinical Regenerative Medicine In Urology eBook. You can read online on your kindle, Android, iPhone, iPad. This multidisciplinary book provides up-to-date information on clinical approaches that combine stem or progenitor cells, biomaterials and scaffolds, growth factors, and other bioactive agents in order to offer improved treatment of urologic disorders including lower urinary tract dysfunction, urinary incontinence, neurogenic bladder, and erectile dysfunction. In providing clinicians and researchers with a broad perspective on the development of regenerative medicine technologies, it will assist in the dissemination of both regenerative medicine principles and a variety of exciting therapeutic options. After an opening section addressing current developments and future perspectives in tissue engineering and regenerative medicine, fundamentals such as cell technologies, biomaterials, bioreactors, bioprinting, and decellularization are covered in detail. The remainder of the book is devoted to the description and evaluation of a range of cell and tissue applications, with individual chapters focusing on the kidney, bladder, urethra, urethral sphincter, and penis and testis.

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Book Detail:
Author: Natalia Grigoryeva
Publisher:
ISBN: 9781839680410
Size: 17.78 MB
Format: PDF, ePub
Release Date: 2020
Category:
Language: en
View: 7394
Status: Available

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Book Description
Download PDF Fluorescence Methods For Investigation Of Living Cells And Microorganisms eBook. You can read online on your kindle, Android, iPhone, iPad. Fluorescence methods play a leading role in the investigation of biological objects. They are the only non-destructive methods for investigating living cells and microorganisms in vivo. Using intrinsic and artificial fluorescence methods provides deep insight into mechanisms underlying physiological and biochemical processes. This book covers a wide range of modern methods involved in experimental biology. It illustrates the use of fluorescence microscopy and spectroscopy, confocal laser scanning microscopy, flow cytometry, delayed fluorescence, pulse-amplitude-modulation fluorometry, and fluorescent dye staining protocols. This book provides an overview of practical and theoretical aspects of fluorescence methods and their successful application in the investigation of static and dynamic processes in living cells and microorganisms.

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Book Detail:
Author: Yuan Lin
Publisher: Frontiers Media SA
ISBN: 2889743667
Size: 46.81 MB
Format: PDF, Docs
Release Date: 2022-02-11
Category: Science
Language: en
View: 1049
Status: Available

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Book Description
Download PDF Membrane And Cytoskeleton Mechanics eBook. You can read online on your kindle, Android, iPhone, iPad.

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Book Detail:
Author: Xiaobing Fu
Publisher: Springer Nature
ISBN: 9811611823
Size: 27.74 MB
Format: PDF, ePub, Docs
Release Date: 2021-08-01
Category: Medical
Language: en
View: 2559
Status: Available

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Book Description
Download PDF Regenerative Medicine In China eBook. You can read online on your kindle, Android, iPhone, iPad. This book includes major issues in wound tissue repair and regeneration in 14 chapters. The topics start from cytological basis, molecular and genetic basis, skin development, to the tissue repair, visceral injury and tissue engineering. In the second part, it introduces Chinese researchers’ contribution in wound repair and regeneration. Specially, it has 3 chapters discussing new technologies in tissue repair and regeneration, and 1 chapter in Traditional Chinese Medicine.

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Book Detail:
Author: Shankar Vallabhajosula
Publisher: Springer Science & Business Media
ISBN: 3540767355
Size: 45.72 MB
Format: PDF, ePub
Release Date: 2009-07-13
Category: Medical
Language: en
View: 997
Status: Available

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Book Description
Download PDF Molecular Imaging eBook. You can read online on your kindle, Android, iPhone, iPad. Radioisotope-based molecular imaging probes provide unprecedented insight into biochemistry and function involved in both normal and disease states of living systems, with unbiased in vivo measurement of regional radiotracer activities offering very high specificity and sensitivity. No other molecular imaging technology including functional magnetic resonance imaging (fMRI) can provide such high sensitivity and specificity at a tracer level. The applications of this technology can be very broad ranging from drug development, pharmacokinetics, clinical investigations, and finally to routine diagnostics in radiology. The design and the development of radiopharmaceuticals for molecular imaging studies using PET/MicroPET or SPECT/MicroSPECT are a unique challenge. This book is intended for a broad audience and written with the main purpose of educating the reader on various aspects including potential clinical utility, limitations of drug development, and regulatory compliance and approvals.

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Book Detail:
Author: Nosheen Masood
Publisher: Springer Nature
ISBN: 9811510679
Size: 68.85 MB
Format: PDF, ePub, Mobi
Release Date: 2020-03-20
Category: Medical
Language: en
View: 849
Status: Available

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Book Description
Download PDF Essentials Of Cancer Genomic Computational Approaches And Precision Medicine eBook. You can read online on your kindle, Android, iPhone, iPad. This book concisely describes the role of omics in precision medicine for cancer therapies. It outlines our current understanding of cancer genomics, shares insights into the process of oncogenesis, and discusses emerging technologies and clinical applications of cancer genomics in prognosis and precision-medicine treatment strategies. It then elaborates on recent advances concerning transcriptomics and translational genomics in cancer diagnosis, clinical applications, and personalized medicine in oncology. Importantly, it also explains the importance of high-performance analytics, predictive modeling, and system biology in cancer research. Lastly, the book discusses current and potential future applications of pharmacogenomics in clinical cancer therapy and cancer drug development.

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Book Detail:
Author: Francois Ferre
Publisher: Springer Science & Business Media
ISBN: 1461241642
Size: 70.92 MB
Format: PDF, Docs
Release Date: 2012-12-06
Category: Medical
Language: en
View: 2630
Status: Available

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Book Description
Download PDF Gene Quantification eBook. You can read online on your kindle, Android, iPhone, iPad. Geneticists and molecular biologists have been interested in quantifying genes and their products for many years and for various reasons (Bishop, 1974). Early molecular methods were based on molecular hybridization, and were devised shortly after Marmur and Doty (1961) first showed that denaturation of the double helix could be reversed - that the process of molecular reassociation was exquisitely sequence dependent. Gillespie and Spiegelman (1965) developed a way of using the method to titrate the number of copies of a probe within a target sequence in which the target sequence was fixed to a membrane support prior to hybridization with the probe - typically a RNA. Thus, this was a precursor to many of the methods still in use, and indeed under development, today. Early examples of the application of these methods included the measurement of the copy numbers in gene families such as the ribosomal genes and the immunoglo bulin family. Amplification of genes in tumors and in response to drug treatment was discovered by this method. In the same period, methods were invented for estimating gene num bers based on the kinetics of the reassociation process - the so-called Cot analysis. This method, which exploits the dependence of the rate of reassociation on the concentration of the two strands, revealed the presence of repeated sequences in the DNA of higher eukaryotes (Britten and Kohne, 1968). An adaptation to RNA, Rot analysis (Melli and Bishop, 1969), was used to measure the abundance of RNAs in a mixed population.

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Book Detail:
Author: Felix Bronner
Publisher: Springer Science & Business Media
ISBN: 9781848820197
Size: 51.16 MB
Format: PDF, Kindle
Release Date: 2009-06-20
Category: Medical
Language: en
View: 615
Status: Available

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Book Description
Download PDF Bone And Cancer eBook. You can read online on your kindle, Android, iPhone, iPad. The fifth in a series of reviews, centered on a single major topic (vol. 1 Bone Formation, vol. 2 Bone Resorption, vol. 3 Engineering of Functional Skeletal Tissues, vol. 4 Osteoarthritis) written by acknowledged authorities in the field, and aimed at researchers, clinicians and others involved in the bone field.

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Book Detail:
Author: Alexzander A. A. Asea
Publisher: Springer
ISBN: 9783319895505
Size: 31.37 MB
Format: PDF
Release Date: 2018-07-12
Category: Medical
Language: en
View: 3987
Status: Available

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Book Description
Download PDF Hsp70 In Human Diseases And Disorders eBook. You can read online on your kindle, Android, iPhone, iPad. The book HSP70 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP70 family - one of the most studied HSP - in human diseases and disorders. Using an integrative approach to expand our current understanding of HSP70 functions, the contributors provide a synopsis of novel mechanisms by which HSP70 is involved in the regulation of human diseases and disorders. Key basic and clinical research laboratories from major universities and academic medical hospitals around the world contribute chapters that review present research activity and importantly project the field into the future. The book is a must read for medical students and residents, clinical and basic science researchers, postdoctoral fellows and graduate students in the fields of Medicine, Physiology, Clinical Trials, Biotechnology, Molecular Medicine and Pathology.

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Book Detail:
Author: Pradip Kumar Dutta
Publisher: Springer
ISBN: 8132225112
Size: 23.74 MB
Format: PDF, Kindle
Release Date: 2015-09-04
Category: Technology & Engineering
Language: en
View: 5911
Status: Available

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Book Description
Download PDF Chitin And Chitosan For Regenerative Medicine eBook. You can read online on your kindle, Android, iPhone, iPad. The book is an excellent reference for scientists, researchers and students working in the field of areas of biopolymeric biomaterials, biomedical engineering, therapeutics, tissue engineering and regenerative medicine. The book is divided into two parts: Part I will focus on the tissue engineering and Part II focuses on therapeutics, functionalization and computer-aided techniques. The book consists of 13 chapters contributed by 20 international contributors who are leading experts in the field of biopolymers and its applications. It will focus on the advancements of chitin and chitosan in regenerative medicine. Regenerative medicine in tissue engineering is the process of replacing or regenerating human cells, tissues, or organs to restore or establish normal function. It is an incredibly progressive field of medicine that may, in the near future, help with the shortage of life-saving organs available through donation for transplantation vis-a-vis regenerative medicine focuses on therapeutics, functionalization and computer-aided techniques. It also covers physical and chemical aspects of chitin and chitosan, structural modifications for biomedical applications, chitosan based scaffolds and biomodelling in tissue engineering, nanomedicines and therapeutic applications. With the broad range of applications, the world is waiting for biopolymers to serve as the basis for regenerative medicine and biomedical applications.

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Book Detail:
Author: Thomas F. Kresina
Publisher: John Wiley & Sons
ISBN: 0471461040
Size: 69.22 MB
Format: PDF, ePub, Mobi
Release Date: 2004-03-24
Category: Science
Language: en
View: 5183
Status: Available

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Book Description
Download PDF An Introduction To Molecular Medicine And Gene Therapy eBook. You can read online on your kindle, Android, iPhone, iPad. An Introduction to Molecular Medicine and Gene Therapy Edited by Thomas F. Kresina, Ph.D. Gene therapy, or the use of genetic manipulation for disease treatment, is derived from advances in genetics, molecular biology, clinical medicine, and human genomics. Molecular medicine, the application of molecular biological techniques to disease treatment and diagnosis, is derived from the development of human organ transplantation, pharmacotherapy, and elucidation of the human genome. An Introduction to Molecular Medicine and Gene Therapy provides a basis for interpreting new clinical and basic research findings in the areas of cloning, gene transfer, and targeting; the applications of genetic medicine to clinical conditions; ethics and governmental regulations; and the burgeoning fields of genomics, biotechnology, and bioinformatics. By dividing the material into three sections - an introduction to basic science, a review of clinical applications, and a discussion of the evolving issues related to gene therapy and molecular medicine-this comprehensive manual describes the basic approaches to the broad range of actual and potential genetic-based therapies. In addition, An Introduction to Molecular Medicine and Gene Therapy: * Covers new frontiers in gene therapy, animal models, vectors, gene targeting, and ethical/legal considerations * Provides organ-based reviews of current studies in gene therapy for monogenetic, multifactoral or polygenic disorders, and infectious diseases * Includes bold-faced terms, key concepts, summaries, and lists of helpful references by subject in each chapter * Contains appendices on commercial implications and a review of the history of gene therapy This textbook offers a clear, concise writing style, drawing upon the expertise of the authors, all renowned researchers in their respective specialties of molecular medicine. Researchers in genetics and molecular medicine will all find An Introduction to Molecular Medicine and Gene Therapy to be an essential guide to the rapidly evolving field of gene therapy and its applications in molecular medicine.

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Book Detail:
Author: Ernesto Carafoli
Publisher: Springer Science & Business Media
ISBN: 1402061919
Size: 20.15 MB
Format: PDF, Mobi
Release Date: 2007-09-29
Category: Medical
Language: en
View: 2647
Status: Available

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Book Description
Download PDF Calcium Signalling And Disease eBook. You can read online on your kindle, Android, iPhone, iPad. Authors highlight several promising discoveries in the field of calcium signaling that provide new information about both genetic and acquired pathologies. Their discussions will give you new insights into the underlying causes of congenital and acquired diseases and point the way to new, even more promising research and therapies.

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Book Detail:
Author:
Publisher: Academic Press
ISBN: 0123983274
Size: 44.53 MB
Format: PDF, ePub
Release Date: 2014-07-29
Category: Science
Language: en
View: 3862
Status: Available

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Book Description
Download PDF Mechanotransduction eBook. You can read online on your kindle, Android, iPhone, iPad. Progress in Molecular Biology and Translational Science provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references. Volume 126 features in-depth reviews that focus on the tools required to investigate mechanotransduction. Additional chapters focus on how we can use these tools to answer fundamental questions about the interaction of physical forces with cell biology, morphogenesis, and function of mature structures. Chapters in the volume are authored by a unique combination of cell biologists and engineers, providing a range of perspectives on mechanotransduction. Provides a unique combination of perspectives from biologists and engineers Engaging to people of many training backgrounds

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Book Detail:
Author: Roland Kaunas
Publisher: CRC Press
ISBN: 1466553820
Size: 14.36 MB
Format: PDF, ePub, Docs
Release Date: 2014-10-23
Category: Medical
Language: en
View: 297
Status: Available

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Book Description
Download PDF Cell And Matrix Mechanics eBook. You can read online on your kindle, Android, iPhone, iPad. Explores a Range of Multiscale Biomechanics/Mechanobiology Concepts Cell and Matrix Mechanics presents cutting-edge research at the molecular, cellular, and tissue levels in the field of cell mechanics. This book involves key experts in the field, and covers crucial areas of cell and tissue mechanics, with an emphasis on the roles of mechanical forces in cell–matrix interactions. Providing material in each chapter that builds on the previous chapters, it effectively integrates length scales and contains, for each length scale, key experimental observations and corresponding quantitative theoretical models. Summarizes the Three Hierarchical Levels of Cell Mechanics The book contains 14 chapters and is organized into three sections. The first section focuses on the molecular level, the second section details mechanics at the cellular level, and the third section explores cellular mechanics at the tissue level. The authors offer a thorough description of the roles of mechanical forces in cell and tissue biology, and include specific examples. They incorporate descriptions of associated theoretical models, and provide the data and modeling framework needed for a multi-scale analysis. In addition, they highlight the pioneering studies in cell–matrix mechanics by Albert K. Harris. The topics covered include: The passive and active mechanical properties of cytoskeletal polymers and associated motor proteins along with the behavior of polymer networks The mechanical properties of the cell membrane, with an emphasis on membrane protein activation caused by membrane forces The hierarchical organization of collagen fibrils, revealing that a delicate balance exists between specific and nonspecific interactions to result in a structure with semicrystalline order as well as loose associations The roles of matrix mechanical properties on cell adhesion and function along with different mechanical mechanisms of cell–cell interactions The effects of mechanical loading on cell cytoskeletal remodeling, summarizing various modeling approaches that explain possible mechanisms regulating the alignment of actin stress fibers in response to stretching The mechanical testing of cell-populated collagen matrices, along with theory relating the passive and active mechanical properties of the engineered tissues Cell migration behavior in 3-D matrices and in collective cell motility The role of mechanics in cartilage development The roles of both cellular and external forces on tissue morphogenesis The roles of mechanical forces on tumor growth and cancer metastasis Cell and Matrix Mechanics succinctly and systematically explains the roles of mechanical forces in cell–matrix biology. Practitioners and researchers in engineering and physics, as well as graduate students in biomedical engineering and mechanical engineering related to mechanobiology, can benefit from this work.

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