Book Detail:
Author: M. Bishr Omary
Publisher: Gulf Professional Publishing
ISBN: 9780125641739
Size: 58.52 MB
Format: PDF, ePub
Release Date: 2004-12-02
Category: Science
Language: en
View: 4945
Status: Available

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Book Description
Download PDF Intermediate Filament Cytoskeleton eBook. You can read online on your kindle, Android, iPhone, iPad. Intermediate filaments are a large family of proteins that are the cytoskeletal elements involved in a number of skin, liver, neuromuscular, cardiac, eye and hair diseases. Intermediate filament genes are regulated in a tissue-and cell type-specific manner and their polymerized protein products protects the cells and tissue they are part of against a variety of mechanical and nonmechanical stresses. This book provides a comprehensive resource of methodology essentials, describing a variety of essential tools and assays for studying intermediate filaments. The book provides user-friendly advice and protocols covering all aspects of intermediate filaments including protein isolation and structure, protein and gene regulation, relationship to disease and apoptosis, and associated proteins. Both mammalian and non-mammalian systems and animal models are covered, making this book a must-have for any investigator wishing to study IF genes or their protein products. * Covers intermediate filaments from crystallography, protein chemistry, cell and molecular biology, microrheology, gene regulation, to animal models and human disease * Practical and user-friendly with detailed "how-to-protocols and "tricks of the trade" * Includes detailed tables of useful reagents, vendors and web links

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Book Detail:
Author: P. Traub
Publisher: Springer Science & Business Media
ISBN: 3642702309
Size: 77.64 MB
Format: PDF, ePub, Docs
Release Date: 2012-12-06
Category: Science
Language: en
View: 6423
Status: Available

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Book Description
Download PDF Intermediate Filaments eBook. You can read online on your kindle, Android, iPhone, iPad. Research on cytoskeletal elements of eukaryotic cells has been expand ing explosively during the past 5 to 10 years. Due largely to the employment of electron and immunofluorescent microscopy, significant results have been obtained which have provided interesting new insights into the dynamics of nucleated cells at the structural, physiological, as well as developmental levels. While a substantial amount of knowledge has accumulated on the function of microfilaments and microtubules, the roles of the third major class of cytoskeletal structures in vertebrate cells, the intermediate filaments, have largely resisted clarification. The investigation of cultured cells and of tissues from various developmental stages has furnished a host of information on the inter-and intracellular distribution of the different types of intermediate filaments and led to the contention that they have a structural and organizing function in the cytoplasm of vertebrate cells. However, the results of recent experimen that vertebrate cells can function perfectly in the tation have shown complete absence of cytoplasmically extended intermediate filament meshworks. It is legitimate to suppose, therefore, that their function in vertebrate cells is much more subtle and complex than generally presumed. Our interest in the structure and function of intermediate filament proteins was initiated approximately 7 years ago while working on the regulation of macromolecular synthesis in picornavirus-infected mam malian cells. In attempts to demonstrate virus-induced changes in the nuclear protein components of the host cells, the nonionic detergent extraction method was used to purify nuclei.

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Book Detail:
Author:
Publisher: Academic Press
ISBN: 0128034912
Size: 66.17 MB
Format: PDF, Docs
Release Date: 2016-01-18
Category: Medical
Language: en
View: 2713
Status: Available

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Book Description
Download PDF Intermediate Filament Proteins eBook. You can read online on your kindle, Android, iPhone, iPad. Intermediate Filament Proteins, the latest volume in the Methods in Enzymology series covers all the intermediate filaments in vertebrates and invertebrates, providing a unique understanding of the multiple different tissue-specific intermediate filaments. This volume also covers the latest methods that are currently being used to study intermediate filament protein function and dynamics. It will be an important companion for any experimentalist interesting in studying this protein family in their cell or organism model system. Focuses on intermediate filaments, including the latest information Provides an up-to-date understanding of the field Contains contributions from the major scientists working and publishing in the field

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Book Detail:
Author: Heide Schatten
Publisher: Springer
ISBN: 1493929046
Size: 40.13 MB
Format: PDF, ePub, Docs
Release Date: 2015-08-21
Category: Science
Language: en
View: 766
Status: Available

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Book Description
Download PDF The Cytoskeleton In Health And Disease eBook. You can read online on your kindle, Android, iPhone, iPad. This volume addresses the structural and functional roles of the cytoskeleton and its dysfunctions which often lead to disease. It provides thorough discussion of microtubules, microfilaments, intermediate filaments, and cytoskeletal functions and dysfunctions in different organ systems. Comprehensive yet concise. The Cytoskeleton In Health And Disease presents cutting-edge discoveries balanced with background information and highlights the new aspects of the research and its impact on the design of new strategies or the identification of new targets for therapeutic intervention. There is a significant need for a book on this topic, as interest in the cytoskeleton continues to grow as causes and cures for cytoskeletal diseases are further explored in biomedical research. This book is essential reading for scientists, students, and teachers interested in expanding their knowledge related to the cytoskeleton. New researchers entering the field will find classic and well as contemporary information not easily found in the current literature or internet resources.

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Book Detail:
Author: Harald Herrmann
Publisher: Springer Science & Business Media
ISBN: 9780306458545
Size: 22.16 MB
Format: PDF
Release Date: 1998-09-30
Category: Science
Language: en
View: 7243
Status: Available

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Book Description
Download PDF Intermediate Filaments eBook. You can read online on your kindle, Android, iPhone, iPad. Comprises 20 contributions on intermediate filament (IF) proteins, providing a comprehensive overview of the essentials of IF research and very recent developments, including many previously unpublished concepts and results. Representative topics include intermediate filament organization during oogenesis and early development in the clawed frog, lessons from keratin transgenic and knockout mice, cytokeratins as markers of differentiation in the diagnosis of epithelial tumors, vimentin and lipid metabolism, and nuclear lamin- binding proteins. Annotation copyrighted by Book News, Inc., Portland, OR

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Book Detail:
Author: A.D. Bershadsky
Publisher: Springer Science & Business Media
ISBN: 1468452789
Size: 53.61 MB
Format: PDF
Release Date: 2012-12-06
Category: Science
Language: en
View: 5591
Status: Available

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Book Description
Download PDF Cytoskeleton eBook. You can read online on your kindle, Android, iPhone, iPad. This book, like other monographs of the Cellular Organelles series, is not a comprehensive review, but an introduction to the study of cytoskeleton. Accordingly, we describe only the main facts and concepts related to cyto skeleton. Needless to say, selection and interpretation was influenced by the personal interests and opinions of the authors, although we attempted to be as fair as possible. We wished to familiarize the reader not only with well established facts, but with current unsolved problems. Therefore, the words "possibly," "maybe," "not known," and "not clear" are much more frequent in this text than in many others. In accordance with the style of the series, relatively short lists of addi tional readings are given at the end of each chapter; these lists contain mostly the recent reviews and a few original papers describing certain phenomena in detail. Few references are cited in the text; these citations are given to help the reader find the source of certain new data and theories, which are not discussed at length in the reviews. In contrast, many well-established facts and widely known theories are not cited.

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Book Detail:
Author: Normand Marceau
Publisher: Biota Publishing
ISBN: 1615045414
Size: 44.54 MB
Format: PDF, ePub, Mobi
Release Date: 2014-06-01
Category: Science
Language: en
View: 469
Status: Available

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Book Description
Download PDF Intermediate Filaments eBook. You can read online on your kindle, Android, iPhone, iPad. Intermediate filaments (IFs), in concert with microfilaments (MFs) and microtubules (MTs), form the cytoskeleton, and each of these fibrillar networks exhibits rather unique structural and functional characteristics. Intermediate filaments were discovered in eukaryotic cells in the late 1960s, and their name comes from the fact that their diameter is intermediate between MFs and MTs. In contrast to the latter, IFs constitute a network that extends from the nuclear envelope throughout the cytoplasm, and in many cases, interact with cell surface domains involved in cell-cell and cell- matrix interactions. Several key features of their expression, assembly, structure and dynamics are highlighted in this eBook. For instance, IF proteins are encoded by several genes, which are classified into six types reflecting the tissues (cells) of origin. Moreover, IF proteins contain a conserved central α-helical (rod) domain flanked by N-terminal (head) and C-terminal (tail) globular domains that enables assembly of fibrous IFs exhibiting a tripartite structure. Although the rod domain is responsible for the formation of the coiled-coil framework and yields the main driving force during the IF protein assembly, the head and tail domains contribute to most of the structural heterogeneity of IF organization and undergo several types of post-translational modifications. Furthermore, the development of gene targeting methods to genetically knockout the expression of the IF genes in mice has uncovered the mechanical versus non-mechanical features of the IF networks, namely, their involvement in cell response to diverse forms of stress, growth stimulation, migration, or death insults. Finally, there is accumulating evidence revealing that the tissue and cell-type expression of IF genes reflects itself in the presence of causal or predisposition mutations responsible for numerous human tissue-specific diseases, known as IF-pathies. Table of Contents: List of Abbreviations / Introduction / IFs as a Multigene Family of Filamentous Proteins / Nuclear Lamina / IF Functional Interplay with Cell Surface Domains and Organelles / IFs and Cell Specialization / IF Relevance to Human Diseases / Conclusion / References / Author Biographies

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Book Detail:
Author: Thomas Dean Pollard
Publisher:
ISBN: 9781621820161
Size: 70.73 MB
Format: PDF
Release Date: 2017
Category: Cell membranes
Language: en
View: 7633
Status: Available

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Book Description
Download PDF The Cytoskeleton eBook. You can read online on your kindle, Android, iPhone, iPad. The cytoskeleton is the intracellular filament system that controls the morphology of a cell, allows it to move, and provides trafficking routes for intracellular transport. It comprises three major filament systems-actin, microtubules, and intermediate filaments-along with a host of adaptors, regulators, molecular motors, and additional structural proteins. This textbook presents a comprehensive and up-to-date view of the cytoskeleton, cataloguing its many different components and explaining how they are functionally integrated in different cellular processes. It starts by laying out the basic molecular hardware, before describing in detail how these components are assembled in cells and linked to neighboring cells and the extracellular matrix to maintain tissue architecture. It then surveys the roles of the cytoskeleton in processes such as intracellular transport, cell motility, signal transduction, and cell division. The book is thus essential reading for students learning about intracellular structure. It also represents a vital reference for all cell and developmental biologists working in this field.

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Book Detail:
Author: R.D. Goldman
Publisher: Springer Science & Business Media
ISBN: 1475796048
Size: 35.85 MB
Format: PDF, Mobi
Release Date: 2013-06-29
Category: Science
Language: en
View: 7711
Status: Available

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Book Description
Download PDF Cellular And Molecular Biology Of Intermediate Filaments eBook. You can read online on your kindle, Android, iPhone, iPad. Research activity on intermediate filaments (IF) has increased dramatically over the past decade. For the most part, this surge of interest is due to their identification as ubiquitous constituents of the cytoskeleton and karyoskeleton (nuclear matrix) of eukaryotic cells and the fact that we know very little regarding their functions. In sharp contrast to the other major cytoskeletal systems, microfilaments and microtubules, IF exhibit a high degree of heterogeneity with regard to their protein subunit composition. Indeed, one can only marvel at the number of different IF polypeptides, their associated proteins (IFAP) and, consequently, the number of genes involved in encoding the multiple constituents of the various IF networks found in different cell types. The chapters in this book demonstrate how various experimental approaches involv ing cellular, molecular, biochemical, and immunological methods have been utilized to generate information regarding the structure and function of IF. To this end, we have gathered together chapters from experts in the major fields of IF research. In each chapter, the authors have combined reviews of the available scientific literature with their own ideas on current and future directions for IF research. The chapters have been divided into five major sections which are concerned with the subcellular organization of IF, the molecular structure of IF, the differential expression of IF genes, descriptions of associ ated proteins involved in the intracellular organization of IF, and finally an analysis of the changes seen in IF in pathological conditions.

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Book Detail:
Author:
Publisher: Academic Press
ISBN: 0128034904
Size: 13.84 MB
Format: PDF, ePub
Release Date: 2016-01-14
Category: Medical
Language: en
View: 6064
Status: Available

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Book Description
Download PDF Intermediate Filament Associated Proteins eBook. You can read online on your kindle, Android, iPhone, iPad. Intermediate Filament Associated Proteins, the latest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in intermediate filament associated proteins and contains sections on such topics as lamin-associated proteins, intermediate filament-associated proteins and plakin, and other cytoskeletal cross-linkers. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods in intermediate filament associated proteins and contains sections on such topics as lamin-associated proteins, intermediate filament-associated proteins and plakin, and other cytoskeletal cross-linkers

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Book Detail:
Author: Bruce Alberts
Publisher:
ISBN: 9780815332183
Size: 15.33 MB
Format: PDF, ePub, Mobi
Release Date: 2004
Category: Cells
Language: en
View: 6895
Status: Available

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Book Description
Download PDF Molecular Biology Of The Cell eBook. You can read online on your kindle, Android, iPhone, iPad.

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Book Detail:
Author: Manfred Schliwa
Publisher: Springer Science & Business Media
ISBN: 3709176670
Size: 72.79 MB
Format: PDF, ePub, Mobi
Release Date: 2012-12-06
Category: Science
Language: en
View: 7020
Status: Available

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Book Description
Download PDF The Cytoskeleton eBook. You can read online on your kindle, Android, iPhone, iPad. The term cytoskeleton has become firmly established in today's scientific vocabulary. Indeed, it is difficult to believe that only ten years ago, it was virtually non-existent. Since then, the modern field of research on the structural organization of the cytoplasm has turned into one of the most productive and rapidly expanding research areas in Cell Biology today. Considerable progress has been made towards the identification of the various structural components of the cytoskeleton and their interactions with one another and with membranes. The first attempts to understand, in molecular terms, complex cellular processes such as shape changes, locomotion, division, and organelle movements have been made. And it is now apparent that the cytoskeleton has impact on other biological processes such as the control of gene expression, protein synthesis, cell cycle regulation, and development. This monograph outlines the basic properties of the major components of the polymeric filament networks and their interactions and associations. Wherever possible, emphasis is placed on more recent references. Any attempt to cover a research field this complex in an introductory mono graph is, by necessity, fragmentary, and oversights or omissions are inevitable. I wish to apologize in advance to all those colleagues who feel that their work is not adequately represented.

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Book Detail:
Author: A. B. Fulton
Publisher: Alice Fulton
ISBN: 9780412255106
Size: 21.28 MB
Format: PDF, Mobi
Release Date: 1984-09-27
Category: Juvenile Nonfiction
Language: en
View: 3100
Status: Available

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Book Description
Download PDF The Cytoskeleton Cellular Architecture And Choreography eBook. You can read online on your kindle, Android, iPhone, iPad. The student of biological science in his final years as an undergraduate and his first years as a graduate is expected to gain some familiarity with current research at the frontiers of his discipline. New research work is published in a perplexing diversity of publications and is inevitably con cerned with the minutiae of the subject. The sheer number of research journals and papers also causes confusion and difficulties of assimilation. Review articles usually presuppose a background knowledge of the field and are inevitably rather restricted in scope. There is thus a need for short but authoritative introductions to those areas of modern biological research which are either not dealt with in standard introductory text books or are not dealt with in sufficient detail to enable the student to go on from them to read scholarly reviews with profit. This series of books is designed to satisfy this need. The authors have been asked to produce a brief outline of their subject assuming that their readers will have read and remembered much of a standard introductory textbook of biology. This outline then sets out to provide by building on this basis, the conceptual framework within which modern research work is progressing and aims to give the reader an indication of the problems, both conceptual and practical, which must be overcome if progress is to be maintained.

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Book Detail:
Author: Johanna Lena Block
Publisher: Göttingen University Press
ISBN: 3863953738
Size: 80.94 MB
Format: PDF, Kindle
Release Date: 2018
Category:
Language: en
View: 2835
Status: Available

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Book Description
Download PDF Stress Strain Behavior Of Single Vimentin Intermediate Filament eBook. You can read online on your kindle, Android, iPhone, iPad. Cells are the basic unit of living organisms and consist of a cytoplasm, which is enclosed by a membrane. As building blocks of life with a plethora of functions, cells have to be equipped with a high degree of mechanical resistance, durability, and variability. In eukaryotic cells three filamentous protein types – actin filaments, microtubules, and intermediate filaments (IFs) – form the so-called cytoskeleton, a network that is known to play a key role for the mechanical properties of cells. Among the three filament systems, IFs are special in terms of, for example, their hierarchical architecture, and their cell-type specific expression. In this thesis, vimentin, an IF mostly found in mesenchymal cells, is studied as a model system to learn more about the mechanical properties of IFs, and the underlying mechanisms that determine their robustness, stiffness, and flexibility. Using a combination of optical trapping and atomic force microcopy experiments and stochastic and numerical modelling, vimentin is found to possess impressive physical properties, such as an extendibility of about 3.6 times its initial length and a tensile memory that can be directly linked to the molecular architecture of the protein and the hierarchical construction of the filament. The experimental results show a clear loading-rate- and strain-dependent behavior of single vimentin IFs supporting the hypothesis that vimentin acts as a “safety belt” for cells, protecting them especially at large and fast deformations. The potential to dissipate a large amount of energy that is attributed to distinct non-equilibrium unfolding and refolding of the α-helices, which are the main structural feature of the vimentin monomer, enables vimentin to act as a shock absorber when exposed to large deformations. In case of cyclic deformations, such as in the cardiovascular system, the observed tensile memory could potentially help cells to be compliant with the repeated strain. In conclusion, vimentin is found to display highly interesting and diverse mechanical properties depending on the applied stress that could be linked to the molecular architecture of the filaments and enable vimentin to determine the mechanical properties of cells to a large extend.

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Book Detail:
Author: Thomas W. Clarkson
Publisher: Springer Science & Business Media
ISBN: 1461321611
Size: 14.34 MB
Format: PDF, ePub, Mobi
Release Date: 2012-12-06
Category: Science
Language: en
View: 1670
Status: Available

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Book Description
Download PDF The Cytoskeleton eBook. You can read online on your kindle, Android, iPhone, iPad. This book is based on reviews and research presentations given at the 16th Rochester International Conference on Environmental Toxicity, entitled liThe Cytoskeleton: A Target for Toxic Agents," held on June 4, 5 and 6 in 1984. The conference provided an in-depth discussion of the effects a~d mechanism of action of some toxic agents on the cytoskeleton. Mamma"lian and other eukaryotic cells contain protein networks within the cytoplasm comprised of microfilaments, intermediate Hlaments and microtubules. These components of the cytoskeleton playa key role in cell shape, motility, intracellular organization and transport, and cell division. Furthermore, the cytoskeleton, via associations with the cell membrane, appears to function in intracellular communication and cellular responses to membrane events. Because of the complex functional roles of the cytoskeleton which vary with cell type, degree of differentiation, and cell cycle, its disruption may result in a variety of cellular changes. This expanding field in cell biology has already attracted the interest of toxicologists and environmental health scientists as a potentially fruitful area of research. Indeed, there is mounting evidence that certain toxic and chemotherapeutic compounds, as well as physical agents such as radiation and hydrostatic pressure, disrupt the normal structure and function of the cytoskeleton. This may be an important step in the overall expression of their action. It was, therefore, an opportune time to hold a conference to encourage the development of this area of toxicology and to suggest directions for future research.

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Book Detail:
Author: David A.D. Parry
Publisher: Springer
ISBN: 9783540590804
Size: 80.65 MB
Format: PDF, Kindle
Release Date: 1995-05-24
Category: Science
Language: en
View: 3578
Status: Available

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Book Description
Download PDF Intermediate Filament Structure eBook. You can read online on your kindle, Android, iPhone, iPad. This book is about the structure and role of intermediate filament (IF) proteins in a diversity of cell types, including neurones and those from the epithelium. Part of the text is devoted to a discussion of the expression of IF proteins, the hierarchical assembly of those proteins into molecules, oligomers, protofilaments, protofibrils and finally intact IF, and the spatial organization of bundles of these IF within the cytoplasm and the nuclear lamina. IF-associated proteins (IFAPs), which may modulate aggregation or function, are also considered in this context. The final topic that is considered centers on the recent and exciting developments in the area of skin diseases, which have been related directly to IF pathology and to mutation in specific keratin chains.

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Book Detail:
Author: Ralph A. Nixon
Publisher: Springer Science & Business Media
ISBN: 1441967877
Size: 69.18 MB
Format: PDF, ePub, Docs
Release Date: 2011-02-04
Category: Medical
Language: en
View: 1082
Status: Available

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Book Description
Download PDF Cytoskeleton Of The Nervous System eBook. You can read online on your kindle, Android, iPhone, iPad. This monograph begins with a general description of the cytoskeleton in axonal development and pathology and then moves to more detailed descriptions of particular components, including microtubules and associated proteins, neurofilaments and interacting proteins, actin and its binding proteins, and glial fibrillary acidic protein. The later chapters focus on the functional significance of the neuronal cytoskeleton in axonal transport and its regulation in health and disease states. The Cytoskeleton of the Nervous System will encourage further development of unifying principles and stimulate new conceptual and technical approaches toward a better understanding of cytoskeleton functions in health and disease.

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Book Detail:
Author: James Spudich
Publisher:
ISBN: 9780824331733
Size: 50.89 MB
Format: PDF, Docs
Release Date: 1996
Category: Actin
Language: en
View: 5221
Status: Available

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Book Description
Download PDF The Cytoskeleton eBook. You can read online on your kindle, Android, iPhone, iPad.

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Book Detail:
Author: Anngrit Maria Lutz
Publisher:
ISBN:
Size: 42.75 MB
Format: PDF, ePub, Mobi
Release Date: 2020
Category:
Language: en
View: 539
Status: Available

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Book Description
Download PDF Effects Of Cell Stretch On The Keratin Intermediate Filament Cytoskeleton In A549 Lung Cells eBook. You can read online on your kindle, Android, iPhone, iPad.

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Book Detail:
Author: Jose C. Jimenez-Lopez
Publisher: BoD – Books on Demand
ISBN: 9535131699
Size: 17.87 MB
Format: PDF, ePub, Docs
Release Date: 2017-05-17
Category: Science
Language: en
View: 2896
Status: Available

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Book Description
Download PDF Cytoskeleton eBook. You can read online on your kindle, Android, iPhone, iPad. The cytoskeleton is a highly dynamic intracellular platform constituted by a three-dimensional network of proteins responsible for key cellular roles as structure and shape, cell growth and development, and offering to the cell with "motility" that being the ability of the entire cell to move and for material to be moved within the cell in a regulated fashion (vesicle trafficking). The present edition of Cytoskeleton provides new insights into the structure-functional features, dynamics, and cytoskeleton's relationship to diseases. The authors' contribution in this book will be of substantial importance to a wide audience such as clinicians, researches, educators, and students interested in getting updated knowledge about molecular basis of cytoskeleton, such as regulation of cell vital processes by actin-binding proteins as cell morphogenesis, motility, their implications in cell signaling, as well as strategies for clinical trial and alternative therapies based in multitargeting molecules to tackle diseases, that is, cancer.

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