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Intermediate Filaments by P. Traub

Intermediate Filament Proteins
Book Detail:
Author: P. Traub
Publisher: Springer Science & Business Media
ISBN: 3642702309
Size: 27.30 MB
Format: PDF, Kindle
Release Date: 2012-12-06
Category: Science
Language: en
View: 2438
Status: Available

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Book Description
Download PDF Intermediate Filaments eBook. You can read online on your kindle, Android, iPhone, iPad. Research on cytoskeletal elements of eukaryotic cells has been expand ing explosively during the past 5 to 10 years. Due largely to the employment of electron and immunofluorescent microscopy, significant results have been obtained which have provided interesting new insights into the dynamics of nucleated cells at the structural, physiological, as well as developmental levels. While a substantial amount of knowledge has accumulated on the function of microfilaments and microtubules, the roles of the third major class of cytoskeletal structures in vertebrate cells, the intermediate filaments, have largely resisted clarification. The investigation of cultured cells and of tissues from various developmental stages has furnished a host of information on the inter-and intracellular distribution of the different types of intermediate filaments and led to the contention that they have a structural and organizing function in the cytoplasm of vertebrate cells. However, the results of recent experimen that vertebrate cells can function perfectly in the tation have shown complete absence of cytoplasmically extended intermediate filament meshworks. It is legitimate to suppose, therefore, that their function in vertebrate cells is much more subtle and complex than generally presumed. Our interest in the structure and function of intermediate filament proteins was initiated approximately 7 years ago while working on the regulation of macromolecular synthesis in picornavirus-infected mam malian cells. In attempts to demonstrate virus-induced changes in the nuclear protein components of the host cells, the nonionic detergent extraction method was used to purify nuclei.

Intermediate Filament Proteins by

Intermediate Filament Proteins
Book Detail:
Author:
Publisher: Academic Press
ISBN: 0128034912
Size: 15.24 MB
Format: PDF, Kindle
Release Date: 2016-01-18
Category: Medical
Language: en
View: 2286
Status: Available

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Download PDF Intermediate Filament Proteins eBook. You can read online on your kindle, Android, iPhone, iPad. Intermediate Filament Proteins, the latest volume in the Methods in Enzymology series covers all the intermediate filaments in vertebrates and invertebrates, providing a unique understanding of the multiple different tissue-specific intermediate filaments. This volume also covers the latest methods that are currently being used to study intermediate filament protein function and dynamics. It will be an important companion for any experimentalist interesting in studying this protein family in their cell or organism model system. Focuses on intermediate filaments, including the latest information Provides an up-to-date understanding of the field Contains contributions from the major scientists working and publishing in the field

Intermediate Filaments by Harald Herrmann

Intermediate Filament Proteins
Book Detail:
Author: Harald Herrmann
Publisher: Springer Science & Business Media
ISBN: 9780306458545
Size: 34.95 MB
Format: PDF
Release Date: 1998-09-30
Category: Science
Language: en
View: 4449
Status: Available

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Book Description
Download PDF Intermediate Filaments eBook. You can read online on your kindle, Android, iPhone, iPad. Comprises 20 contributions on intermediate filament (IF) proteins, providing a comprehensive overview of the essentials of IF research and very recent developments, including many previously unpublished concepts and results. Representative topics include intermediate filament organization during oogenesis and early development in the clawed frog, lessons from keratin transgenic and knockout mice, cytokeratins as markers of differentiation in the diagnosis of epithelial tumors, vimentin and lipid metabolism, and nuclear lamin- binding proteins. Annotation copyrighted by Book News, Inc., Portland, OR

Intermediate Filament Cytoskeleton by M. Bishr Omary

Intermediate Filament Proteins
Book Detail:
Author: M. Bishr Omary
Publisher: Gulf Professional Publishing
ISBN: 9780125641739
Size: 65.42 MB
Format: PDF, ePub, Docs
Release Date: 2004-12-02
Category: Science
Language: en
View: 757
Status: Available

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Download PDF Intermediate Filament Cytoskeleton eBook. You can read online on your kindle, Android, iPhone, iPad. Intermediate filaments are a large family of proteins that are the cytoskeletal elements involved in a number of skin, liver, neuromuscular, cardiac, eye and hair diseases. Intermediate filament genes are regulated in a tissue-and cell type-specific manner and their polymerized protein products protects the cells and tissue they are part of against a variety of mechanical and nonmechanical stresses. This book provides a comprehensive resource of methodology essentials, describing a variety of essential tools and assays for studying intermediate filaments. The book provides user-friendly advice and protocols covering all aspects of intermediate filaments including protein isolation and structure, protein and gene regulation, relationship to disease and apoptosis, and associated proteins. Both mammalian and non-mammalian systems and animal models are covered, making this book a must-have for any investigator wishing to study IF genes or their protein products. * Covers intermediate filaments from crystallography, protein chemistry, cell and molecular biology, microrheology, gene regulation, to animal models and human disease * Practical and user-friendly with detailed "how-to-protocols and "tricks of the trade" * Includes detailed tables of useful reagents, vendors and web links

Intermediate Filament Proteins Advances In Research And Application 2011 Edition by

Intermediate Filament Proteins
Book Detail:
Author:
Publisher: ScholarlyEditions
ISBN: 146494072X
Size: 64.79 MB
Format: PDF, ePub, Mobi
Release Date: 2012-01-09
Category: Medical
Language: en
View: 5644
Status: Available

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Book Description
Download PDF Intermediate Filament Proteins Advances In Research And Application 2011 Edition eBook. You can read online on your kindle, Android, iPhone, iPad. Intermediate Filament Proteins: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Intermediate Filament Proteins in a concise format. The editors have built Intermediate Filament Proteins: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Intermediate Filament Proteins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Intermediate Filament Proteins: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Intermediate Filament Proteins by Roy Quinlan

Intermediate Filament Proteins
Book Detail:
Author: Roy Quinlan
Publisher:
ISBN:
Size: 40.47 MB
Format: PDF, ePub, Mobi
Release Date: 1994
Category: Cytoplasmic filaments
Language: en
View: 115
Status: Available

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Download PDF Intermediate Filament Proteins eBook. You can read online on your kindle, Android, iPhone, iPad.

Intermediate Filaments by Jesus Paramio

Intermediate Filament Proteins
Book Detail:
Author: Jesus Paramio
Publisher: Springer Science & Business Media
ISBN: 0387337814
Size: 21.32 MB
Format: PDF, ePub, Docs
Release Date: 2007-06-07
Category: Science
Language: en
View: 1238
Status: Available

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Book Description
Download PDF Intermediate Filaments eBook. You can read online on your kindle, Android, iPhone, iPad. Intermediate Filaments focuses on desmin and other intermediate filaments in disease and health. This new volume will serve as a resource for graduate students and researchers in the field.

Intermediate Filaments by Normand Marceau

Intermediate Filament Proteins
Book Detail:
Author: Normand Marceau
Publisher: Biota Publishing
ISBN: 1615045414
Size: 33.69 MB
Format: PDF, ePub
Release Date: 2014-06-01
Category: Science
Language: en
View: 7079
Status: Available

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Book Description
Download PDF Intermediate Filaments eBook. You can read online on your kindle, Android, iPhone, iPad. Intermediate filaments (IFs), in concert with microfilaments (MFs) and microtubules (MTs), form the cytoskeleton, and each of these fibrillar networks exhibits rather unique structural and functional characteristics. Intermediate filaments were discovered in eukaryotic cells in the late 1960s, and their name comes from the fact that their diameter is intermediate between MFs and MTs. In contrast to the latter, IFs constitute a network that extends from the nuclear envelope throughout the cytoplasm, and in many cases, interact with cell surface domains involved in cell-cell and cell- matrix interactions. Several key features of their expression, assembly, structure and dynamics are highlighted in this eBook. For instance, IF proteins are encoded by several genes, which are classified into six types reflecting the tissues (cells) of origin. Moreover, IF proteins contain a conserved central α-helical (rod) domain flanked by N-terminal (head) and C-terminal (tail) globular domains that enables assembly of fibrous IFs exhibiting a tripartite structure. Although the rod domain is responsible for the formation of the coiled-coil framework and yields the main driving force during the IF protein assembly, the head and tail domains contribute to most of the structural heterogeneity of IF organization and undergo several types of post-translational modifications. Furthermore, the development of gene targeting methods to genetically knockout the expression of the IF genes in mice has uncovered the mechanical versus non-mechanical features of the IF networks, namely, their involvement in cell response to diverse forms of stress, growth stimulation, migration, or death insults. Finally, there is accumulating evidence revealing that the tissue and cell-type expression of IF genes reflects itself in the presence of causal or predisposition mutations responsible for numerous human tissue-specific diseases, known as IF-pathies. Table of Contents: List of Abbreviations / Introduction / IFs as a Multigene Family of Filamentous Proteins / Nuclear Lamina / IF Functional Interplay with Cell Surface Domains and Organelles / IFs and Cell Specialization / IF Relevance to Human Diseases / Conclusion / References / Author Biographies

Cellular And Molecular Biology Of Intermediate Filaments by R.D. Goldman

Intermediate Filament Proteins
Book Detail:
Author: R.D. Goldman
Publisher: Springer Science & Business Media
ISBN: 1475796048
Size: 63.63 MB
Format: PDF, Kindle
Release Date: 2013-06-29
Category: Science
Language: en
View: 2407
Status: Available

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Book Description
Download PDF Cellular And Molecular Biology Of Intermediate Filaments eBook. You can read online on your kindle, Android, iPhone, iPad. Research activity on intermediate filaments (IF) has increased dramatically over the past decade. For the most part, this surge of interest is due to their identification as ubiquitous constituents of the cytoskeleton and karyoskeleton (nuclear matrix) of eukaryotic cells and the fact that we know very little regarding their functions. In sharp contrast to the other major cytoskeletal systems, microfilaments and microtubules, IF exhibit a high degree of heterogeneity with regard to their protein subunit composition. Indeed, one can only marvel at the number of different IF polypeptides, their associated proteins (IFAP) and, consequently, the number of genes involved in encoding the multiple constituents of the various IF networks found in different cell types. The chapters in this book demonstrate how various experimental approaches involv ing cellular, molecular, biochemical, and immunological methods have been utilized to generate information regarding the structure and function of IF. To this end, we have gathered together chapters from experts in the major fields of IF research. In each chapter, the authors have combined reviews of the available scientific literature with their own ideas on current and future directions for IF research. The chapters have been divided into five major sections which are concerned with the subcellular organization of IF, the molecular structure of IF, the differential expression of IF genes, descriptions of associ ated proteins involved in the intracellular organization of IF, and finally an analysis of the changes seen in IF in pathological conditions.

Intermediate Filament Proteins Advances In Research And Application 2013 Edition by

Intermediate Filament Proteins
Book Detail:
Author:
Publisher: ScholarlyEditions
ISBN: 1481689029
Size: 66.27 MB
Format: PDF, ePub
Release Date: 2013-06-21
Category: Medical
Language: en
View: 2060
Status: Available

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Book Description
Download PDF Intermediate Filament Proteins Advances In Research And Application 2013 Edition eBook. You can read online on your kindle, Android, iPhone, iPad. Intermediate Filament Proteins—Advances in Research and Application: 2013 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about ZZZAdditional Research in a compact format. The editors have built Intermediate Filament Proteins—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Intermediate Filament Proteins—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Intermediate Filament Associated Proteins by

Intermediate Filament Proteins
Book Detail:
Author:
Publisher: Academic Press
ISBN: 0128034904
Size: 62.93 MB
Format: PDF, Kindle
Release Date: 2016-01-14
Category: Medical
Language: en
View: 5332
Status: Available

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Book Description
Download PDF Intermediate Filament Associated Proteins eBook. You can read online on your kindle, Android, iPhone, iPad. Intermediate Filament Associated Proteins, the latest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in intermediate filament associated proteins and contains sections on such topics as lamin-associated proteins, intermediate filament-associated proteins and plakin, and other cytoskeletal cross-linkers. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods in intermediate filament associated proteins and contains sections on such topics as lamin-associated proteins, intermediate filament-associated proteins and plakin, and other cytoskeletal cross-linkers

A Comparative Analysis Of Intermediate Filament Proteins In Bovine Heart Purkinje Fibers And Gastric Smooth Muscle by

Intermediate Filament Proteins
Book Detail:
Author:
Publisher:
ISBN:
Size: 74.76 MB
Format: PDF, Mobi
Release Date: 1984
Category: Intermediate filament proteins
Language: en
View: 708
Status: Available

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Book Description
Download PDF A Comparative Analysis Of Intermediate Filament Proteins In Bovine Heart Purkinje Fibers And Gastric Smooth Muscle eBook. You can read online on your kindle, Android, iPhone, iPad.

Molecular Biology Of The Cell by Bruce Alberts

Intermediate Filament Proteins
Book Detail:
Author: Bruce Alberts
Publisher:
ISBN: 9780815332183
Size: 57.22 MB
Format: PDF, Kindle
Release Date: 2004
Category: Cells
Language: en
View: 5717
Status: Available

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Book Description
Download PDF Molecular Biology Of The Cell eBook. You can read online on your kindle, Android, iPhone, iPad.

Type Iii Intermediate Filament Proteins by Martin Kooijman

Intermediate Filament Proteins
Book Detail:
Author: Martin Kooijman
Publisher:
ISBN:
Size: 70.29 MB
Format: PDF, ePub, Mobi
Release Date: 1995
Category:
Language: en
View: 2111
Status: Available

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Download PDF Type Iii Intermediate Filament Proteins eBook. You can read online on your kindle, Android, iPhone, iPad.

The Cytoskeleton by Manfred Schliwa

Intermediate Filament Proteins
Book Detail:
Author: Manfred Schliwa
Publisher: Springer Science & Business Media
ISBN: 3709176670
Size: 49.54 MB
Format: PDF, ePub, Docs
Release Date: 2012-12-06
Category: Science
Language: en
View: 6116
Status: Available

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Book Description
Download PDF The Cytoskeleton eBook. You can read online on your kindle, Android, iPhone, iPad. The term cytoskeleton has become firmly established in today's scientific vocabulary. Indeed, it is difficult to believe that only ten years ago, it was virtually non-existent. Since then, the modern field of research on the structural organization of the cytoplasm has turned into one of the most productive and rapidly expanding research areas in Cell Biology today. Considerable progress has been made towards the identification of the various structural components of the cytoskeleton and their interactions with one another and with membranes. The first attempts to understand, in molecular terms, complex cellular processes such as shape changes, locomotion, division, and organelle movements have been made. And it is now apparent that the cytoskeleton has impact on other biological processes such as the control of gene expression, protein synthesis, cell cycle regulation, and development. This monograph outlines the basic properties of the major components of the polymeric filament networks and their interactions and associations. Wherever possible, emphasis is placed on more recent references. Any attempt to cover a research field this complex in an introductory mono graph is, by necessity, fragmentary, and oversights or omissions are inevitable. I wish to apologize in advance to all those colleagues who feel that their work is not adequately represented.

Intermediate Filament Mechanics Across Scales From Single Filaments To Single Interactions And Networks In Cells by Anna Veronika Schepers

Intermediate Filament Proteins
Book Detail:
Author: Anna Veronika Schepers
Publisher: Universitätsverlag Göttingen
ISBN: 3863955676
Size: 44.98 MB
Format: PDF, ePub, Mobi
Release Date: 2022
Category:
Language: en
View: 2842
Status: Available

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Book Description
Download PDF Intermediate Filament Mechanics Across Scales From Single Filaments To Single Interactions And Networks In Cells eBook. You can read online on your kindle, Android, iPhone, iPad. The mechanical properties of cells are largely determined by the cytoskeleton. The cytoskeleton is an intricate and complex structure formed by protein filaments, motor proteins, and crosslinkers. The three main types of protein filaments are microtubules, actin filaments, and intermediate filaments ( IFs ). Whereas the proteins that form microtubules and actin filaments are exceptionally conserved throughout cell types and organisms, the family of IFs is diverse. For example, the IF protein vimentin is expressed in relatively motile fibroblasts, and keratin IFs are found in epithelial cells. This variety of IF proteins might therefore be linked to the various mechanical properties of different cell types. In the scope of this thesis, I combine studies of IF mechanics on different time scales and in systems of increasing complexity, from single filaments to networks in cells. This multiscale approach allows for the simplification necessary to interpret observations while adding increasing physiological context in subsequent experiments. We especially focus on the tunability of the IF mechanics by environmental cues in these increasingly complex systems. In a series of experiments, including single filament elongation studies, single filament stretching measurements with optical tweezers, filament-filament interaction measurements with four optical tweezers, microrheology, and isotropic cell stretching, we characterize how electrostatic (pH and ion concentration) and hydrophobic interactions (detergent) provide various mechanisms by which the mechanics of the IF cytoskeleton can be tuned. These studies reveal how small changes, such as charge shifts, influence IF mechanics on multiple scales. In combination with simulations, we determine the mechanisms by which charge shifts alter single vimentin filament mechanics and we extract energy landscapes for interactions between single filaments. Such insights will provide a deeper understanding of the mechanisms by which cells can maintain their integrity and adapt to the mechanical requirements set by their environment.